6SWG

Crystal structure of the TASOR-Periphilin core complex

Summary for 6SWG

Entry DOI	10.2210/pdb6swg/pdb
Descriptor	Periphilin-1, Protein TASOR, SULFATE ION (3 entities in total)
Functional Keywords	nuclear protein; transcriptional repressor; epigenetic silencing; histone h3 lysine 9 methylation (h3k9me3); transposable element; line1 element; low-complexity sequence; liquid-liquid phase separation (llps); membrane-less compartment; rna-binding protein, gene regulation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	31657.79
Authors	Prigozhin, D.M.,Freund, S.M.V.,Modis, Y. (deposition date: 2019-09-20, release date: 2020-08-05, Last modification date: 2020-10-21)
Primary citation	Prigozhin, D.M.,Douse, C.H.,Farleigh, L.E.,Albecka, A.,Tchasovnikarova, I.A.,Timms, R.T.,Oda, S.I.,Adolf, F.,Freund, S.M.V.,Maslen, S.,Lehner, P.J.,Modis, Y. Periphilin self-association underpins epigenetic silencing by the HUSH complex. Nucleic Acids Res., 48:10313-10328, 2020 Cited by PubMed: 32976585 DOI: 10.1093/nar/gkaa785 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.51 Å)

Structure validation