6MHA

dHP1 Chromodomain Y24W variant bound to histone H3 peptide containing trimethyllysine

Summary for 6MHA

• Entry DOI: 10.2210/pdb6mha/pdb
• Related: 1KNE
• Descriptor: Heterochromatin protein 1, histone H3 peptide containing trimethyllysine, H3K9me3 (3 entities in total)
• Functional Keywords: cation-pi epigenetics trimethyllysine chromodomain, protein binding
• Biological source: Drosophila melanogaster (Fruit fly); More
• Total number of polymer chains: 2
• Total formula weight: 7293.13

Authors

Brustad, E.M.,Krone, M.W.,Albanese, K.I.,Waters, M.L. (deposition date: 2018-09-17, release date: 2019-09-25, Last modification date: 2023-10-11)

• Primary citation: Krone, M.W.,Albanese, K.I.,Guseman, A.J.,He, C.Q.,Lee, G.Y.,Houk, K.N.,Brustad, E.M.,Waters, M.L.; Thermodynamic consequences of Tyr to Trp mutations in the cation-pi-mediated binding of trimethyllysine by the HP1 chromodomain; Chem Sci, 11:3495-3500, 2020; DOI: 10.1039/D0SC00227E

Experimental method

X-RAY DIFFRACTION (1.497 Å)