3A27
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![BU of 3a27 by Molmil](/molmil-images/mine/3a27) | Crystal structure of M. jannaschii TYW2 in complex with AdoMet | Descriptor: | S-ADENOSYLMETHIONINE, Uncharacterized protein MJ1557 | Authors: | Umitsu, M, Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2009-04-28 | Release date: | 2009-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.005 Å) | Cite: | Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2 Proc.Natl.Acad.Sci.USA, 106, 2009
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2RDA
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3A5R
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![BU of 3a5r by Molmil](/molmil-images/mine/3a5r) | Benzalacetone synthase from Rheum palmatum complexed with 4-coumaroyl-primed monoketide intermediate | Descriptor: | 4'-HYDROXYCINNAMIC ACID, Benzalacetone synthase | Authors: | Morita, H, Kato, R, Abe, I, Sugio, S, Kohno, T. | Deposit date: | 2009-08-10 | Release date: | 2010-01-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A structure-based mechanism for benzalacetone synthase from Rheum palmatum Proc.Natl.Acad.Sci.USA, 107, 2010
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2ZXU
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![BU of 2zxu by Molmil](/molmil-images/mine/2zxu) | Crystal structure of tRNA modification enzyme MiaA in the complex with tRNA(Phe) and DMASPP | Descriptor: | DIMETHYLALLYL S-THIOLODIPHOSPHATE, MAGNESIUM ION, tRNA delta(2)-isopentenylpyrophosphate transferase, ... | Authors: | Sakai, J, Yao, M, Chimnaronk, S, Tanaka, I. | Deposit date: | 2009-01-07 | Release date: | 2009-05-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Snapshots of dynamics in synthesizing N(6)-isopentenyladenosine at the tRNA anticodon Biochemistry, 48, 2009
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5ZRV
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![BU of 5zrv by Molmil](/molmil-images/mine/5zrv) | Structure of human mitochondrial trifunctional protein, octamer | Descriptor: | Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta | Authors: | Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J. | Deposit date: | 2018-04-25 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Cryo-EM structure of human mitochondrial trifunctional protein Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1SYN
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![BU of 1syn by Molmil](/molmil-images/mine/1syn) | E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, THYMIDYLATE SYNTHASE | Authors: | Stout, T.J, Stroud, R.M. | Deposit date: | 1995-09-19 | Release date: | 1996-01-29 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition. Structure, 4, 1996
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1TEE
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1TH5
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![BU of 1th5 by Molmil](/molmil-images/mine/1th5) | Solution structure of C-terminal domain of NifU-like protein from Oryza sativa | Descriptor: | NifU1 | Authors: | Kumeta, H, Ogura, K, Asayama, M, Katoh, S, Katoh, E, Inagaki, F. | Deposit date: | 2004-06-01 | Release date: | 2005-09-27 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The NMR structure of the domain II of a chloroplastic NifU-like protein OsNifU1A. J.Biomol.Nmr, 38, 2007
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3A0R
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![BU of 3a0r by Molmil](/molmil-images/mine/3a0r) | Crystal structure of histidine kinase ThkA (TM1359) in complex with response regulator protein TrrA (TM1360) | Descriptor: | MERCURY (II) ION, Response regulator, Sensor protein | Authors: | Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. | Deposit date: | 2009-03-24 | Release date: | 2009-10-20 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009
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3A26
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![BU of 3a26 by Molmil](/molmil-images/mine/3a26) | Crystal structure of P. horikoshii TYW2 in complex with MeSAdo | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, TETRAETHYLENE GLYCOL, Uncharacterized protein PH0793 | Authors: | Umitsu, M, Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2009-04-28 | Release date: | 2009-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2 Proc.Natl.Acad.Sci.USA, 106, 2009
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4H5D
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![BU of 4h5d by Molmil](/molmil-images/mine/4h5d) | Crystal structure of human FPPS in ternary complex with YS0470 and inorganic pyrophosphate | Descriptor: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | Authors: | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | Deposit date: | 2012-09-18 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Struct.Biol., 12, 2012
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3I9S
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![BU of 3i9s by Molmil](/molmil-images/mine/3i9s) | Structure from the mobile metagenome of V.cholerae. Integron cassette protein VCH_CASS6 | Descriptor: | CHLORIDE ION, Integron cassette protein, SULFATE ION | Authors: | Deshpande, C.N, Sureshan, V, Harrop, S.J, Boucher, Y, Xu, X, Cui, H, Edwards, A, Savchenko, A, Joachimiak, A, Chang, C, Stokes, H.W, Curmi, P.M.G, Mabbutt, B.C, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-07-13 | Release date: | 2009-08-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure from the mobile metagenome of V.cholerae. Integron cassette protein VCH_CASS6 To be Published
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2REE
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6A2O
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![BU of 6a2o by Molmil](/molmil-images/mine/6a2o) | Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5,5'-[propane-1,3-diylbis(oxy-4,1-phenylene)]bis(6-ethylpyrimidine-2,4-diamine), Bifunctional dihydrofolate reductase-thymidylate synthase, ... | Authors: | Chitnumsub, P, Jaruwat, A, Tarnchampoo, B, Yuthavong, Y. | Deposit date: | 2018-06-12 | Release date: | 2019-04-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance. ACS Med Chem Lett, 9, 2018
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5TRL
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4MHD
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![BU of 4mhd by Molmil](/molmil-images/mine/4mhd) | Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with spermidine | Descriptor: | SPERMIDINE, Spermidine n1-acetyltransferase | Authors: | Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Kuhn, M.L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2013-08-29 | Release date: | 2013-09-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | A Novel Polyamine Allosteric Site of SpeG from Vibrio cholerae Is Revealed by Its Dodecameric Structure. J.Mol.Biol., 427, 2015
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4HBJ
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1WL5
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![BU of 1wl5 by Molmil](/molmil-images/mine/1wl5) | Human cytosolic acetoacetyl-CoA thiolase | Descriptor: | GLYCEROL, SULFATE ION, acetyl-Coenzyme A acetyltransferase 2 | Authors: | Kursula, P, Fukao, T, Kondo, N, Wierenga, R.K. | Deposit date: | 2004-06-20 | Release date: | 2005-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | High Resolution Crystal Structures of Human Cytosolic Thiolase (CT): A Comparison of the Active Sites of Human CT, Bacterial Thiolase, and Bacterial KAS I J.Mol.Biol., 347, 2005
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1WK4
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![BU of 1wk4 by Molmil](/molmil-images/mine/1wk4) | Crystal structure of ttk003001606 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ttk003001606 | Authors: | Kaminishi, T, Sakai, H, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2004-05-30 | Release date: | 2004-11-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of ttk003001606 To be Published
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3A5Q
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![BU of 3a5q by Molmil](/molmil-images/mine/3a5q) | Benzalacetone synthase from Rheum palmatum | Descriptor: | Benzalacetone synthase | Authors: | Morita, H, Kato, R, Abe, I, Sugio, S, Kohno, T. | Deposit date: | 2009-08-10 | Release date: | 2010-01-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A structure-based mechanism for benzalacetone synthase from Rheum palmatum Proc.Natl.Acad.Sci.USA, 107, 2010
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5TVJ
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![BU of 5tvj by Molmil](/molmil-images/mine/5tvj) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with CoA and inhibitor 2k*: 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium | Descriptor: | 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium, CHLORIDE ION, COENZYME A, ... | Authors: | Gajadeera, C.S, Garzan, A, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V. | Deposit date: | 2016-11-09 | Release date: | 2017-03-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors. ACS Infect Dis, 3, 2017
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3ICN
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![BU of 3icn by Molmil](/molmil-images/mine/3icn) | Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with isopentenyl pyrophosphate and 3-Fluoro-1-(2-hydroxy-2,2-bis-phosphono-ethyl)-pyridinium | Descriptor: | 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, ... | Authors: | Amzel, L.M, Huang, C.H, Gabelli, S.B, Oldfield, E. | Deposit date: | 2009-07-17 | Release date: | 2010-02-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins, 78, 2010
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1T3D
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![BU of 1t3d by Molmil](/molmil-images/mine/1t3d) | Crystal structure of Serine Acetyltransferase from E.coli at 2.2A | Descriptor: | CYSTEINE, Serine acetyltransferase | Authors: | Pye, V.E, Tingey, A.P, Robson, R.L, Moody, P.C.E. | Deposit date: | 2004-04-26 | Release date: | 2004-07-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Structure and Mechanism of Serine Acetyltransferase from Escherichia coli J.Biol.Chem., 279, 2004
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2RL2
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4HHE
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![BU of 4hhe by Molmil](/molmil-images/mine/4hhe) | Quinolinate synthase from Pyrococcus furiosus | Descriptor: | CHLORIDE ION, Quinolinate synthase A | Authors: | Soriano, E.V, Zhang, Y, Settembre, E.C, Colabroy, K, Sanders, J.M, Dorrestein, P.C, Begley, T.P, Ealick, S.E. | Deposit date: | 2012-10-09 | Release date: | 2013-08-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.797 Å) | Cite: | Active-site models for complexes of quinolinate synthase with substrates and intermediates. Acta Crystallogr.,Sect.D, 69, 2013
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