8BVX
 
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3EHM
 | | Structure of BT1043 | | Descriptor: | 1,2-ETHANEDIOL, SusD homolog | | Authors: | Koropatkin, N.M, Smith, T.J. | | Deposit date: | 2008-09-13 | | Release date: | 2009-05-12 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of a SusD homologue, BT1043, involved in mucin O-glycan utilization in a prominent human gut symbiont.
Biochemistry, 48, 2009
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6I9Q
 | | Structure of the mouse CD98 heavy chain ectodomain | | Descriptor: | 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, CHLORIDE ION | | Authors: | Schiefner, A, Deuschle, F.-C, Skerra, A. | | Deposit date: | 2018-11-24 | | Release date: | 2019-04-17 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural differences between the ectodomains of murine and human CD98hc.
Proteins, 87, 2019
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7VNO
 | | Structure of aminotransferase | | Descriptor: | 1,2-ETHANEDIOL, 454aa long hypothetical 4-aminobutyrate aminotransferase, GLYCEROL, ... | | Authors: | Sakuraba, H, Ohshida, T, Ohshima, T. | | Deposit date: | 2021-10-11 | | Release date: | 2022-03-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of a novel type of ornithine delta-aminotransferase from the hyperthermophilic archaeon Pyrococcus horikoshii.
Int.J.Biol.Macromol., 208, 2022
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5BOE
 | | Crystal structure of Staphylococcus aureus enolase in complex with PEP | | Descriptor: | Enolase, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Wang, C.L, Wu, Y.F, Han, L, Wu, M.H, Zhang, X, Zang, J.Y. | | Deposit date: | 2015-05-27 | | Release date: | 2015-12-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Octameric structure of Staphylococcus aureus enolase in complex with phosphoenolpyruvate
Acta Crystallogr.,Sect.D, 71, 2015
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9BFG
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8F8E
 | | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-8268 compound | | Descriptor: | (3P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-3-(4-chloro-2-fluorophenyl)-1H-pyrazole-4-carboxamide, CITRIC ACID, DDB1- and CUL4-associated factor 1 | | Authors: | Kimani, S, Li, A, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Wilson, B, Al-Awar, R, Vedadi, M, Brown, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-11-21 | | Release date: | 2023-03-01 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-8268 compound
To be published
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6IRZ
 | | Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH and m7G-capped RNA | | Descriptor: | 1,2-ETHANEDIOL, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, PDX1 C-terminal-inhibiting factor 1, ... | | Authors: | Hirano, S, Nishimasu, H, Ishitani, R, Nureki, O. | | Deposit date: | 2018-11-15 | | Release date: | 2018-12-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase.
Science, 363, 2019
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7VNT
 | | Structure of aminotransferase-substrate complex | | Descriptor: | 1,2-ETHANEDIOL, 454aa long hypothetical 4-aminobutyrate aminotransferase, GLYCEROL, ... | | Authors: | Sakuraba, H, Ohshida, T, Ohshima, T. | | Deposit date: | 2021-10-12 | | Release date: | 2022-03-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Crystal structure of a novel type of ornithine delta-aminotransferase from the hyperthermophilic archaeon Pyrococcus horikoshii.
Int.J.Biol.Macromol., 208, 2022
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6IVO
 | | Crystal structure of a membrane protein P208A | | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | | Deposit date: | 2018-12-04 | | Release date: | 2019-11-06 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
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4UDA
 | | MR in complex with dexamethasone | | Descriptor: | DEXAMETHASONE, GLYCEROL, MINERALOCORTICOID RECEPTOR, ... | | Authors: | Edman, K, Hogner, A, Hussein, A, Bjursell, M, Aagaard, A, Backstrom, S, Bodin, C, Wissler, L, Jellesmark-Jensen, T, Cavallin, A, Karlsson, U, Nilsson, E, Lecina, D, Takahashi, R, Grebner, C, Lepisto, M, Guallar, V. | | Deposit date: | 2014-12-09 | | Release date: | 2015-11-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
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8F7B
 | | LRRC8A(T48D):C conformation 2 top focus | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | | Authors: | Kern, D.M, Brohawn, S.G. | | Deposit date: | 2022-11-18 | | Release date: | 2023-03-08 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
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8F74
 | | LRRC8A(T48D):C conformation 2 top focus | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | | Authors: | Kern, D.M, Brohawn, S.G. | | Deposit date: | 2022-11-18 | | Release date: | 2023-03-08 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
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9GLF
 | | Anthraquinone Pigment Production Regulated by Cinnamic Acid | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, AntI, ... | | Authors: | Su, L, Schmalhofer, M, Grammbitter, G.L.C, Paczia, N, Glatter, T, Groll, M, Bode, H.B. | | Deposit date: | 2024-08-27 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | The Isopropylstilbene Precursor Cinnamic Acid Inhibits Anthraquinone Pigment Production by Targeting AntI.
J.Am.Chem.Soc., 147, 2025
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9BFK
 | | Cryo-EM structure of human CHT1 in the ML352 bound state | | Descriptor: | 4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]-N-{[3-(propan-2-yl)-1,2-oxazol-5-yl]methyl}benzamide, High affinity choline transporter 1 | | Authors: | Xue, J, Jiang, Y. | | Deposit date: | 2024-04-18 | | Release date: | 2024-11-06 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Structural mechanisms of human sodium-coupled high-affinity choline transporter CHT1.
Cell Discov, 10, 2024
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6I72
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9BYU
 | | Structure and stability of an apo thermophilic esterase that hydrolyzes polyhydroxybutyrate | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Esterase, PHB depolymerase family, ... | | Authors: | Thomas, G.M, Quirk, S, Huard, D.J.E, Lieberman, R.L. | | Deposit date: | 2024-05-24 | | Release date: | 2024-11-06 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structure and stability of an apo thermophilic esterase that hydrolyzes polyhydroxybutyrate.
Acta Crystallogr D Struct Biol, 80, 2024
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3JZS
 | | Human MDM2 liganded with a 12mer peptide inhibitor (pDIQ) | | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase Mdm2, pDIQ peptide (12mer) | | Authors: | Schonbrunn, E, Phan, J. | | Deposit date: | 2009-09-24 | | Release date: | 2009-11-10 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
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5NXY
 | | Crystal structure of OpuAC from B. subtilis in complex with Arsenobetaine | | Descriptor: | 1,2-ETHANEDIOL, 2-(trimethyl-lambda~5~-arsanyl)ethanol, Osmotically activated L-carnitine/choline ABC transporter substrate-binding protein OpuCC | | Authors: | Hofmann, T, Bremer, E, Schmitt, L, Smits, S. | | Deposit date: | 2017-05-11 | | Release date: | 2018-03-14 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Arsenobetaine: an ecophysiologically important organoarsenical confers cytoprotection against osmotic stress and growth temperature extremes.
Environ. Microbiol., 20, 2018
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8EMZ
 | | Structure of GII.17 norovirus in complex with Nanobody 2 | | Descriptor: | 1,2-ETHANEDIOL, GII.17 P domain, Nanobody 2 | | Authors: | Kher, G, Sabin, C, Pancera, M, Koromyslova, A, Hansman, G. | | Deposit date: | 2022-09-28 | | Release date: | 2023-03-15 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Direct Blockade of the Norovirus Histo-Blood Group Antigen Binding Pocket by Nanobodies.
J.Virol., 97, 2023
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4ZEK
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9KNG
 | | Crystal structure of human ERRg LBD in complex with 4034496 | | Descriptor: | 6-methyl-1,3-benzothiazole-2,4-diamine, Estrogen-related receptor gamma, Nuclear receptor-interacting protein 1 | | Authors: | Xu, T, Wang, N, Liu, J. | | Deposit date: | 2024-11-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-09-10 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Identification of indoles as potential endogenous ligands of ERR gamma and their modulation on drug binding.
Acta Pharmacol.Sin., 46, 2025
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5KON
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8IWO
 | | The rice Na+/H+ antiporter SOS1 in an auto-inhibited state | | Descriptor: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate, OsSOS1 | | Authors: | Zhang, X.Y, Tang, L.H, Zhang, C.R, Nie, J.W, Chen, Y.H. | | Deposit date: | 2023-03-30 | | Release date: | 2023-11-22 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na + /H + antiporter.
Nat.Plants, 9, 2023
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9BCV
 | | Cyclase domain of GC-A bound to ANP | | Descriptor: | Atrial natriuretic peptide receptor 1, Fab fragment, MAGNESIUM ION, ... | | Authors: | Liu, S, Huang, X. | | Deposit date: | 2024-04-09 | | Release date: | 2024-11-27 | | Last modified: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Architecture and activation of single-pass transmembrane receptor guanylyl cyclase.
Nat.Struct.Mol.Biol., 32, 2025
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