8TI1
 
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8TI2
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8TSP
 | | Open, inward-facing MsbA structure (OIF1) | | Descriptor: | ATP-binding transport protein MsbA | | Authors: | Yang, B, Zhang, T, Lyu, J, Laganowsky, A.D, Zhao, M. | | Deposit date: | 2023-08-11 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Native mass spectrometry captures snapshots of the MsbA transport cycle
To Be Published
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8TSR
 | | Open, inward-facing MsbA structure (OIF4) | | Descriptor: | ATP-binding transport protein MsbA | | Authors: | Yang, B, Zhang, T, Lyu, J, Laganowsky, A.D, Zhao, M. | | Deposit date: | 2023-08-11 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Native mass spectrometry captures snapshots of the MsbA transport cycle
To Be Published
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8TSQ
 | | Open, inward-facing MsbA structure (OIF2) | | Descriptor: | ATP-binding transport protein MsbA | | Authors: | Yang, B, Zhang, T, Lyu, J, Laganowsky, A.D, Zhao, M. | | Deposit date: | 2023-08-11 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Native mass spectrometry captures snapshots of the MsbA transport cycle
To Be Published
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8TSO
 | | KDL bound, nucleotide-free MsbA in open, outward-facing conformation | | Descriptor: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ATP-binding transport protein MsbA, PENTAETHYLENE GLYCOL MONODECYL ETHER | | Authors: | Yang, B, Zhang, T, Lyu, J, Laganowsky, A.D, Zhao, M. | | Deposit date: | 2023-08-11 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Native mass spectrometry captures snapshots of the MsbA transport cycle
To Be Published
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8TSS
 | | Open, inward-facing MsbA structure (OIF3) | | Descriptor: | ATP-binding transport protein MsbA | | Authors: | Yang, B, Zhang, T, Lyu, J, Laganowsky, A.D, Zhao, M. | | Deposit date: | 2023-08-11 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Native mass spectrometry captures snapshots of the MsbA transport cycle
To Be Published
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8UBR
 | | Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with CFTRinh-172 and ATP/Mg | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Young, P.G, Fiedorczuk, K, Chen, J. | | Deposit date: | 2023-09-24 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis for CFTR inhibition by CFTR inh -172.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8V81
 | | Phosphorylated, ATP-bound, inhibitor 172-bound E1371Q human cystic fibrosis transmembrane conductance regulator | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Gao, X, Hwang, T. | | Deposit date: | 2023-12-04 | | Release date: | 2024-07-17 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore.
Nat Commun, 15, 2024
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8V7Z
 | | Phosphorylated, ATP-bound, E1371Q human cystic fibrosis transmembrane conductance regulator (E1371Q-CFTR) | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | | Authors: | Gao, X, Hwang, T. | | Deposit date: | 2023-12-04 | | Release date: | 2024-07-17 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore.
Nat Commun, 15, 2024
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8VSI
 | | Mechanistic Insights Revealed by YbtPQ in the Occluded State | | Descriptor: | ABC transporter ATP-binding protein, ADP ORTHOVANADATE, MAGNESIUM ION, ... | | Authors: | Hu, W, Parkinson, C, Zheng, H. | | Deposit date: | 2024-01-24 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Mechanistic Insights Revealed by YbtPQ in the Occluded State.
Biomolecules, 14, 2024
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8IZ9
 | | cryo-EM structure of PGE1-bound hMRP4 | | Descriptor: | 7-[(1R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid, ATP-binding cassette sub-family C member 4 | | Authors: | Liu, Z.M, Huang, Y. | | Deposit date: | 2023-04-06 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | cryo-EM structure of PGE1-bound hMRP4
To Be Published
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8IZA
 | | cryo-EM structure of ATP-bound hMRP4 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 4, MAGNESIUM ION | | Authors: | Liu, Z.M, Huang, Y. | | Deposit date: | 2023-04-06 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | cryo-EM structure of ATP-bound hMRP4
To Be Published
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8JW4
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8JWI
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8JWG
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8JWF
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8JVH
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8K7C
 | | Outward-facing structure of human ABCB6 W546A mutant (ADP/VO4-bound) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family B member 6, MAGNESIUM ION, ... | | Authors: | Jin, M.S, Lee, S.S, Park, J.G, Jang, E, Choi, S.H, Kim, S, Kim, J.W. | | Deposit date: | 2023-07-26 | | Release date: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state.
Commun Biol, 6, 2023
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8K7B
 | | post-occluded structure of human ABCB6 W546A mutant (ADP/VO4-bound) | | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ADP ORTHOVANADATE, ATP-binding cassette sub-family B member 6, ... | | Authors: | Jin, M.S, Lee, S.S, Park, J.G, Jang, E, Choi, S.H, Kim, S, Kim, J.W. | | Deposit date: | 2023-07-26 | | Release date: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state.
Commun Biol, 6, 2023
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8K7A
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8K4B
 | | Cryo-EM structure of nucleotide-bound ComA with ZinC ion | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Competence factor transporting ATP-binding protein/permease ComA, ZINC ION | | Authors: | Yu, L, Xin, X, Min, L, Feng, H. | | Deposit date: | 2023-07-17 | | Release date: | 2023-10-11 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of peptide secretion for Quorum sensing by ComA.
Nat Commun, 14, 2023
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8JX7
 | | Cryo-EM structure of human ABC transporter ABCC2 | | Descriptor: | ATP-binding cassette sub-family C member 2 | | Authors: | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | | Deposit date: | 2023-06-30 | | Release date: | 2024-01-03 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain.
Nat Commun, 15, 2024
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8JY5
 | | Cryo-EM structure of human ABC transporter ABCC2 in apo" state | | Descriptor: | ATP-binding cassette sub-family C member 2 | | Authors: | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | | Deposit date: | 2023-07-03 | | Release date: | 2024-01-03 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (4.17 Å) | | Cite: | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain.
Nat Commun, 15, 2024
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8JY4
 | | Cryo-EM structure of human ABC transporter ABCC2 in apo' state | | Descriptor: | ATP-binding cassette sub-family C member 2 | | Authors: | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | | Deposit date: | 2023-07-02 | | Release date: | 2024-01-03 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain.
Nat Commun, 15, 2024
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