8TI1

Cryo-EM structure of a SUR1/Kir6.2-Q52R ATP-sensitive potassium channel in the presence of PIP2 in the open conformation

Summary for 8TI1

• Entry DOI: 10.2210/pdb8ti1/pdb
• Related: 8TI2
• EMDB information: 41277 41278 43766
• Descriptor: ATP-sensitive inward rectifier potassium channel 11, SUR1, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate, ... (8 entities in total)
• Functional Keywords: atp-sensitive potassium channel, katp channel, sur1, kir6.2-q52r, potassium transport, metabolic sensor, diabetes, phospholipid binding, pip2, transport protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 8
• Total formula weight: 902471.99

Authors

Driggers, C.M.,Shyng, S.-L. (deposition date: 2023-07-18, release date: 2024-04-03)

• Primary citation: Driggers, C.M.,Kuo, Y.Y.,Zhu, P.,ElSheikh, A.,Shyng, S.L.; Structure of an open K ATP channel reveals tandem PIP 2 binding sites mediating the Kir6.2 and SUR1 regulatory interface.; Nat Commun, 15:2502-2502, 2024; PubMed: 38509107; DOI: 10.1038/s41467-024-46751-5

Experimental method

ELECTRON MICROSCOPY (2.9 Å)