8TI2
Cryo-EM structure of a SUR1/Kir6.2-Q52R ATP-sensitive potassium channel in the presence of PIP2 in the open conformation
Summary for 8TI2
Entry DOI | 10.2210/pdb8ti2/pdb |
EMDB information | 41277 41278 |
Descriptor | ATP-sensitive inward rectifier potassium channel 11, SUR1, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate, ... (8 entities in total) |
Functional Keywords | atp-sensitive potassium channel, katp channel, sur1, kir6.2-q52r, potassium transport, metabolic sensor, diabetes, phospholipid binding, pip2, transport protein |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 8 |
Total formula weight | 902471.99 |
Authors | |
Primary citation | Driggers, C.M.,Kuo, Y.Y.,Zhu, P.,ElSheikh, A.,Shyng, S.L. Structure of an open K ATP channel reveals tandem PIP 2 binding sites mediating the Kir6.2 and SUR1 regulatory interface. Nat Commun, 15:2502-2502, 2024 Cited by PubMed: 38509107DOI: 10.1038/s41467-024-46751-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.28 Å) |
Structure validation
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