8TI2
Cryo-EM structure of a SUR1/Kir6.2-Q52R ATP-sensitive potassium channel in the presence of PIP2 in the open conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, D, E (A, B, C, D) | ATP-sensitive inward rectifier potassium channel 11 | polymer | 390 | 43690.8 | 4 | UniProt (P70673) Pfam (PF01007) Pfam (PF17655) | Rattus norvegicus (Norway rat) | BIR,Inward rectifier K(+) channel Kir6.2,Potassium channel,inwardly rectifying subfamily J member 11 |
| 2 | B, F, G, H (E, H, G, F) | SUR1 | polymer | 1582 | 177296.6 | 4 | UniProt (A0A1S4NYG1) Pfam (PF00664) Pfam (PF00005) | Mesocricetus auratus (golden hamster) | |
| 3 | AA, FA, I, N, S... (G, F, A, E, B...) | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 8 | Chemie (PT5) | |||
| 4 | J, K, L, M (A) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 5 | BA, GA, O, W (G, F, E, H) | DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE | non-polymer | 692.0 | 4 | Chemie (PEF) | |||
| 6 | CA, DA, HA, IA, P... (G, F, E, H) | O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | non-polymer | 792.1 | 8 | Chemie (P5S) | |||
| 7 | EA, JA, R, Z (G, F, E, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 8 | KA, LA, MA, NA (A, B, C, D) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 390 (UniProt: P70673)
| PDB | External Database | Details |
|---|---|---|
| Arg 52 | Gln 52 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 883949.6 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 18522.4 | |
| All* | Total formula weight | 902472.0 |
