8TI2
Cryo-EM structure of a SUR1/Kir6.2-Q52R ATP-sensitive potassium channel in the presence of PIP2 in the open conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, D, E (A, B, C, D) | ATP-sensitive inward rectifier potassium channel 11 | polymer | 390 | 43690.8 | 4 | UniProt (P70673) Pfam (PF01007) Pfam (PF17655) | Rattus norvegicus (Norway rat) | BIR,Inward rectifier K(+) channel Kir6.2,Potassium channel,inwardly rectifying subfamily J member 11 |
| 2 | B, F, G, H (E, H, G, F) | SUR1 | polymer | 1582 | 177296.6 | 4 | UniProt (A0A1S4NYG1) | Mesocricetus auratus (golden hamster) | |
| 3 | AA, FA, I, N, S... (G, F, A, E, B...) | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 8 | Chemie (PT5) PubChem (21584053) PubChem (24742075) PubChem (25021172) PubChem (49867532) PubChem (53731018) PubChem (74343116) PubChem (46891800) PubChem (644093) PubChem (88368868) PubChem (101127471) PubChem (53480261) PubChem (137349554) PubChem (146672970) PubChem (162802760) PubChem (177693253) PubChem (101103400) PubChem (5497157) PubChem (137349667) PubChem (155387720) | |||
| 4 | J, K, L, M (A) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) PubChem (813) | |||
| 5 | BA, GA, O, W (G, F, E, H) | DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE | non-polymer | 692.0 | 4 | Chemie (PEF) PubChem (65109) PubChem (15859389) PubChem (445468) | |||
| 6 | CA, DA, HA, IA, P... (G, F, E, H) | O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | non-polymer | 792.1 | 8 | Chemie (P5S) PubChem (9547096) PubChem (15409341) PubChem (165429904) PubChem (125040277) PubChem (9547075) PubChem (10417847) PubChem (133612130) | |||
| 7 | EA, JA, R, Z (G, F, E, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 8 | KA, LA, MA, NA (A, B, C, D) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 390 (UniProt: P70673)
| PDB | External Database | Details |
|---|---|---|
| Arg 52 | Gln 52 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 883949.6 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 18522.4 | |
| All* | Total formula weight | 902472.0 |
