8TI2

Cryo-EM structure of a SUR1/Kir6.2-Q52R ATP-sensitive potassium channel in the presence of PIP2 in the open conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001508	biological_process	action potential
A	0001666	biological_process	response to hypoxia
A	0001669	cellular_component	acrosomal vesicle
A	0002931	biological_process	response to ischemia
A	0003229	biological_process	ventricular cardiac muscle tissue development
A	0005242	molecular_function	inward rectifier potassium channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005635	cellular_component	nuclear envelope
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005886	cellular_component	plasma membrane
A	0006006	biological_process	glucose metabolic process
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006915	biological_process	apoptotic process
A	0006950	biological_process	response to stress
A	0008282	cellular_component	inward rectifying potassium channel
A	0008340	biological_process	determination of adult lifespan
A	0009410	biological_process	response to xenobiotic stimulus
A	0014704	cellular_component	intercalated disc
A	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
A	0016020	cellular_component	membrane
A	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
A	0030315	cellular_component	T-tubule
A	0030506	molecular_function	ankyrin binding
A	0030673	cellular_component	axolemma
A	0031072	molecular_function	heat shock protein binding
A	0031669	biological_process	cellular response to nutrient levels
A	0032355	biological_process	response to estradiol
A	0033198	biological_process	response to ATP
A	0033574	biological_process	response to testosterone
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0034765	biological_process	regulation of monoatomic ion transmembrane transport
A	0042383	cellular_component	sarcolemma
A	0042391	biological_process	regulation of membrane potential
A	0042734	cellular_component	presynaptic membrane
A	0043025	cellular_component	neuronal cell body
A	0044325	molecular_function	transmembrane transporter binding
A	0046676	biological_process	negative regulation of insulin secretion
A	0046872	molecular_function	metal ion binding
A	0050796	biological_process	regulation of insulin secretion
A	0050877	biological_process	nervous system process
A	0061762	biological_process	CAMKK-AMPK signaling cascade
A	0070852	cellular_component	cell body fiber
A	0071316	biological_process	cellular response to nicotine
A	0071333	biological_process	cellular response to glucose stimulus
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0098662	biological_process	inorganic cation transmembrane transport
A	0098978	cellular_component	glutamatergic synapse
A	0099505	biological_process	regulation of presynaptic membrane potential
A	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A	1903078	biological_process	positive regulation of protein localization to plasma membrane
A	1904638	biological_process	response to resveratrol
A	1990573	biological_process	potassium ion import across plasma membrane
B	0000166	molecular_function	nucleotide binding
B	0001508	biological_process	action potential
B	0001666	biological_process	response to hypoxia
B	0001669	cellular_component	acrosomal vesicle
B	0002931	biological_process	response to ischemia
B	0003229	biological_process	ventricular cardiac muscle tissue development
B	0005242	molecular_function	inward rectifier potassium channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005768	cellular_component	endosome
B	0005886	cellular_component	plasma membrane
B	0006006	biological_process	glucose metabolic process
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006915	biological_process	apoptotic process
B	0006950	biological_process	response to stress
B	0008282	cellular_component	inward rectifying potassium channel
B	0008340	biological_process	determination of adult lifespan
B	0009410	biological_process	response to xenobiotic stimulus
B	0014704	cellular_component	intercalated disc
B	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
B	0016020	cellular_component	membrane
B	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
B	0030315	cellular_component	T-tubule
B	0030506	molecular_function	ankyrin binding
B	0030673	cellular_component	axolemma
B	0031072	molecular_function	heat shock protein binding
B	0031669	biological_process	cellular response to nutrient levels
B	0032355	biological_process	response to estradiol
B	0033198	biological_process	response to ATP
B	0033574	biological_process	response to testosterone
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0034765	biological_process	regulation of monoatomic ion transmembrane transport
B	0042383	cellular_component	sarcolemma
B	0042391	biological_process	regulation of membrane potential
B	0042734	cellular_component	presynaptic membrane
B	0043025	cellular_component	neuronal cell body
B	0044325	molecular_function	transmembrane transporter binding
B	0046676	biological_process	negative regulation of insulin secretion
B	0046872	molecular_function	metal ion binding
B	0050796	biological_process	regulation of insulin secretion
B	0050877	biological_process	nervous system process
B	0061762	biological_process	CAMKK-AMPK signaling cascade
B	0070852	cellular_component	cell body fiber
B	0071316	biological_process	cellular response to nicotine
B	0071333	biological_process	cellular response to glucose stimulus
B	0071356	biological_process	cellular response to tumor necrosis factor
B	0098662	biological_process	inorganic cation transmembrane transport
B	0098978	cellular_component	glutamatergic synapse
B	0099505	biological_process	regulation of presynaptic membrane potential
B	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B	1903078	biological_process	positive regulation of protein localization to plasma membrane
B	1904638	biological_process	response to resveratrol
B	1990573	biological_process	potassium ion import across plasma membrane
C	0000166	molecular_function	nucleotide binding
C	0001508	biological_process	action potential
C	0001666	biological_process	response to hypoxia
C	0001669	cellular_component	acrosomal vesicle
C	0002931	biological_process	response to ischemia
C	0003229	biological_process	ventricular cardiac muscle tissue development
C	0005242	molecular_function	inward rectifier potassium channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005635	cellular_component	nuclear envelope
C	0005737	cellular_component	cytoplasm
C	0005768	cellular_component	endosome
C	0005886	cellular_component	plasma membrane
C	0006006	biological_process	glucose metabolic process
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006915	biological_process	apoptotic process
C	0006950	biological_process	response to stress
C	0008282	cellular_component	inward rectifying potassium channel
C	0008340	biological_process	determination of adult lifespan
C	0009410	biological_process	response to xenobiotic stimulus
C	0014704	cellular_component	intercalated disc
C	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
C	0016020	cellular_component	membrane
C	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
C	0030315	cellular_component	T-tubule
C	0030506	molecular_function	ankyrin binding
C	0030673	cellular_component	axolemma
C	0031072	molecular_function	heat shock protein binding
C	0031669	biological_process	cellular response to nutrient levels
C	0032355	biological_process	response to estradiol
C	0033198	biological_process	response to ATP
C	0033574	biological_process	response to testosterone
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0034765	biological_process	regulation of monoatomic ion transmembrane transport
C	0042383	cellular_component	sarcolemma
C	0042391	biological_process	regulation of membrane potential
C	0042734	cellular_component	presynaptic membrane
C	0043025	cellular_component	neuronal cell body
C	0044325	molecular_function	transmembrane transporter binding
C	0046676	biological_process	negative regulation of insulin secretion
C	0046872	molecular_function	metal ion binding
C	0050796	biological_process	regulation of insulin secretion
C	0050877	biological_process	nervous system process
C	0061762	biological_process	CAMKK-AMPK signaling cascade
C	0070852	cellular_component	cell body fiber
C	0071316	biological_process	cellular response to nicotine
C	0071333	biological_process	cellular response to glucose stimulus
C	0071356	biological_process	cellular response to tumor necrosis factor
C	0098662	biological_process	inorganic cation transmembrane transport
C	0098978	cellular_component	glutamatergic synapse
C	0099505	biological_process	regulation of presynaptic membrane potential
C	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C	1903078	biological_process	positive regulation of protein localization to plasma membrane
C	1904638	biological_process	response to resveratrol
C	1990573	biological_process	potassium ion import across plasma membrane
D	0000166	molecular_function	nucleotide binding
D	0001508	biological_process	action potential
D	0001666	biological_process	response to hypoxia
D	0001669	cellular_component	acrosomal vesicle
D	0002931	biological_process	response to ischemia
D	0003229	biological_process	ventricular cardiac muscle tissue development
D	0005242	molecular_function	inward rectifier potassium channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005635	cellular_component	nuclear envelope
D	0005737	cellular_component	cytoplasm
D	0005768	cellular_component	endosome
D	0005886	cellular_component	plasma membrane
D	0006006	biological_process	glucose metabolic process
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0006915	biological_process	apoptotic process
D	0006950	biological_process	response to stress
D	0008282	cellular_component	inward rectifying potassium channel
D	0008340	biological_process	determination of adult lifespan
D	0009410	biological_process	response to xenobiotic stimulus
D	0014704	cellular_component	intercalated disc
D	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
D	0016020	cellular_component	membrane
D	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
D	0030315	cellular_component	T-tubule
D	0030506	molecular_function	ankyrin binding
D	0030673	cellular_component	axolemma
D	0031072	molecular_function	heat shock protein binding
D	0031669	biological_process	cellular response to nutrient levels
D	0032355	biological_process	response to estradiol
D	0033198	biological_process	response to ATP
D	0033574	biological_process	response to testosterone
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034702	cellular_component	monoatomic ion channel complex
D	0034765	biological_process	regulation of monoatomic ion transmembrane transport
D	0042383	cellular_component	sarcolemma
D	0042391	biological_process	regulation of membrane potential
D	0042734	cellular_component	presynaptic membrane
D	0043025	cellular_component	neuronal cell body
D	0044325	molecular_function	transmembrane transporter binding
D	0046676	biological_process	negative regulation of insulin secretion
D	0046872	molecular_function	metal ion binding
D	0050796	biological_process	regulation of insulin secretion
D	0050877	biological_process	nervous system process
D	0061762	biological_process	CAMKK-AMPK signaling cascade
D	0070852	cellular_component	cell body fiber
D	0071316	biological_process	cellular response to nicotine
D	0071333	biological_process	cellular response to glucose stimulus
D	0071356	biological_process	cellular response to tumor necrosis factor
D	0098662	biological_process	inorganic cation transmembrane transport
D	0098978	cellular_component	glutamatergic synapse
D	0099505	biological_process	regulation of presynaptic membrane potential
D	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D	1903078	biological_process	positive regulation of protein localization to plasma membrane
D	1904638	biological_process	response to resveratrol
D	1990573	biological_process	potassium ion import across plasma membrane
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0006813	biological_process	potassium ion transport
E	0008281	molecular_function	sulfonylurea receptor activity
E	0008282	cellular_component	inward rectifying potassium channel
E	0009410	biological_process	response to xenobiotic stimulus
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
E	0042383	cellular_component	sarcolemma
E	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
E	0046872	molecular_function	metal ion binding
E	0055085	biological_process	transmembrane transport
E	0098655	biological_process	monoatomic cation transmembrane transport
E	0098662	biological_process	inorganic cation transmembrane transport
E	0140359	molecular_function	ABC-type transporter activity
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0006813	biological_process	potassium ion transport
F	0008281	molecular_function	sulfonylurea receptor activity
F	0008282	cellular_component	inward rectifying potassium channel
F	0009410	biological_process	response to xenobiotic stimulus
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
F	0042383	cellular_component	sarcolemma
F	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
F	0046872	molecular_function	metal ion binding
F	0055085	biological_process	transmembrane transport
F	0098655	biological_process	monoatomic cation transmembrane transport
F	0098662	biological_process	inorganic cation transmembrane transport
F	0140359	molecular_function	ABC-type transporter activity
G	0000166	molecular_function	nucleotide binding
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006813	biological_process	potassium ion transport
G	0008281	molecular_function	sulfonylurea receptor activity
G	0008282	cellular_component	inward rectifying potassium channel
G	0009410	biological_process	response to xenobiotic stimulus
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
G	0042383	cellular_component	sarcolemma
G	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
G	0046872	molecular_function	metal ion binding
G	0055085	biological_process	transmembrane transport
G	0098655	biological_process	monoatomic cation transmembrane transport
G	0098662	biological_process	inorganic cation transmembrane transport
G	0140359	molecular_function	ABC-type transporter activity
H	0000166	molecular_function	nucleotide binding
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0006813	biological_process	potassium ion transport
H	0008281	molecular_function	sulfonylurea receptor activity
H	0008282	cellular_component	inward rectifying potassium channel
H	0009410	biological_process	response to xenobiotic stimulus
H	0016020	cellular_component	membrane
H	0016887	molecular_function	ATP hydrolysis activity
H	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
H	0042383	cellular_component	sarcolemma
H	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
H	0046872	molecular_function	metal ion binding
H	0055085	biological_process	transmembrane transport
H	0098655	biological_process	monoatomic cation transmembrane transport
H	0098662	biological_process	inorganic cation transmembrane transport
H	0140359	molecular_function	ABC-type transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL

Chain	Residue	Details
E	LEU830-LEU844
E	PHE1482-PHE1496

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"PubMed","id":"38509107","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TI1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	160
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38509107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8TI1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"38509107","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TI1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"38509107","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TI1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q14654","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38509107","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TI1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by MAPK1","evidences":[{"source":"UniProtKB","id":"Q14654","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---