8UBR

Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with CFTRinh-172 and ATP/Mg

Summary for 8UBR

Entry DOI	10.2210/pdb8ubr/pdb
EMDB information	42101
Descriptor	Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (7 entities in total)
Functional Keywords	inhibitor, cftr, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	172100.30
Authors	Young, P.G.,Fiedorczuk, K.,Chen, J. (deposition date: 2023-09-24, release date: 2024-02-21, Last modification date: 2024-03-20)
Primary citation	Young, P.G.,Levring, J.,Fiedorczuk, K.,Blanchard, S.C.,Chen, J. Structural basis for CFTR inhibition by CFTR inh -172. Proc.Natl.Acad.Sci.USA, 121:e2316675121-e2316675121, 2024 Cited by PubMed: 38422021 DOI: 10.1073/pnas.2316675121 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.7 Å)

Structure validation