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1FQR
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BU of 1fqr by Molmil
X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE, COBALT (II) ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-06
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1FR7
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BU of 1fr7 by Molmil
X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-07
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
7C5W
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BU of 7c5w by Molmil
Crystal structure of the iota-carbonic anhydrase from cyanobacterium complexed with iodide
Descriptor: IODIDE ION, iota-carbonic anhydrase
Authors:Senda, M, Senda, T.
Deposit date:2020-05-20
Release date:2021-04-28
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of a novel type of carbonic anhydrase that acts without metal cofactors.
Bmc Biol., 19, 2021
7C5X
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BU of 7c5x by Molmil
Crystal structure of the iota-carbonic anhydrase from eukaryotic microalga complexed with bicarbonate
Descriptor: BICARBONATE ION, iota-carbonic anhydrase
Authors:Senda, M, Senda, T.
Deposit date:2020-05-20
Release date:2021-04-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Characterization of a novel type of carbonic anhydrase that acts without metal cofactors.
Bmc Biol., 19, 2021
7C5V
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BU of 7c5v by Molmil
Crystal structure of the iota-carbonic anhydrase from cyanobacterium complexed with bicarbonate
Descriptor: BICARBONATE ION, iota-carbonic anhydrase
Authors:Senda, M, Senda, T.
Deposit date:2020-05-20
Release date:2021-04-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Characterization of a novel type of carbonic anhydrase that acts without metal cofactors.
Bmc Biol., 19, 2021
7C5Y
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BU of 7c5y by Molmil
Crystal structure of the iota-carbonic anhydrase from eukaryotic microalga complexed with iodide
Descriptor: IODIDE ION, iota-carbonic anhydrase
Authors:Senda, M, Senda, T.
Deposit date:2020-05-20
Release date:2021-04-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of a novel type of carbonic anhydrase that acts without metal cofactors.
Bmc Biol., 19, 2021
6YJN
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BU of 6yjn by Molmil
Crystal structure of beta carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei.
Descriptor: Beta carbonic anhydrase, ZINC ION
Authors:Angeli, A, Ferraroni, M.
Deposit date:2020-04-03
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of a Tetrameric Type II beta-Carbonic Anhydrase from the Pathogenic BacteriumBurkholderia pseudomallei.
Molecules, 25, 2020
5UMC
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BU of 5umc by Molmil
Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography
Descriptor: Carbonic anhydrase 2, GLYCEROL, UNKNOWN LIGAND, ...
Authors:Peat, T.S, Angeli, A, Tanini, D, Bartolucci, G, Capperucci, A, Supuran, C.T, Carta, F.
Deposit date:2017-01-26
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.
ACS Med Chem Lett, 8, 2017
2AX2
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BU of 2ax2 by Molmil
Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II
Descriptor: Carbonic anhydrase II, ZINC ION
Authors:Budayova-Spano, M, Fisher, S.Z, Dauvergne, M.T, Silverman, D.N, Myles, D.A.A, McKenna, R.M.
Deposit date:2005-09-02
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.
Acta Crystallogr.,Sect.F, 62, 2006
5WLV
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BU of 5wlv by Molmil
Carbonic Anhydrase II in complex with aryloxy-2-hydroxypropylammine sulfonamide
Descriptor: 4-{(2R)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}-N-[2-(4-sulfamoylphenyl)ethyl]benzamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ...
Authors:Lomelino, C.L, Andring, J.T, McKenna, R.
Deposit date:2017-07-27
Release date:2018-08-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of beta-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
J. Med. Chem., 61, 2018
2NWO
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BU of 2nwo by Molmil
Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
5WLT
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BU of 5wlt by Molmil
Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
Descriptor: 4-{(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Lomelino, C.L, Andring, J.T, McKenna, R.
Deposit date:2017-07-27
Release date:2018-08-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Discovery of beta-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
J. Med. Chem., 61, 2018
2NNV
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BU of 2nnv by Molmil
Structure of inhibitor binding to Carbonic Anhydrase II
Descriptor: Carbonic anhydrase 2, ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE, GLYCEROL, ...
Authors:Christianson, D.W, Jude, K.M.
Deposit date:2006-10-24
Release date:2007-05-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II.
J.Am.Chem.Soc., 129, 2007
1FSN
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BU of 1fsn by Molmil
X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE II
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-11
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1FSR
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BU of 1fsr by Molmil
X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE II, COPPER (II) ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-11
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
6OE0
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BU of 6oe0 by Molmil
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
Descriptor: 2-(2,4-dioxo-1,3-diazaspiro[4.6]undecan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Peat, T.S.
Deposit date:2019-03-27
Release date:2019-06-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.
Eur.J.Med.Chem., 177, 2019
6ODZ
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BU of 6odz by Molmil
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
Descriptor: 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Peat, T.S.
Deposit date:2019-03-27
Release date:2019-06-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.
Eur.J.Med.Chem., 177, 2019
6GDC
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BU of 6gdc by Molmil
Human Carbonic Anhydrase II in complex with Benzenesulfonamide
Descriptor: Carbonic anhydrase 2, MERCURIBENZOIC ACID, MERCURY (II) ION, ...
Authors:Gloeckner, S, Heine, A, Klebe, G.
Deposit date:2018-04-23
Release date:2019-05-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.079 Å)
Cite:Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors.
Acs Chem.Biol., 15, 2020
5A6H
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BU of 5a6h by Molmil
Synthesis, carbonic anhydrase inhibition and protein X-ray structure of the unusual natural product primary sulfonamide Psammaplin C
Descriptor: CARBONIC ANHYDRASE 2, DIMETHYL SULFOXIDE, PSAMMAPLIN C, ...
Authors:Mujumdar, P, Supuran, C.T, Peat, T.S, Poulsen, S.
Deposit date:2015-06-26
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition and Protein X-Ray Structures of Psammaplin C.
J.Med.Chem., 59, 2016
4YWP
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BU of 4ywp by Molmil
Sucrose Binding Site in genetically engineered Carbonic anhydrase IX
Descriptor: Carbonic anhydrase 2, ZINC ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose
Authors:Pinard, M.A, Aggarwal, M.
Deposit date:2015-03-20
Release date:2015-10-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.
Acta Crystallogr F Struct Biol Commun, 71, 2015
6G3Q
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BU of 6g3q by Molmil
Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine
Descriptor: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ...
Authors:Ferraroni, M, Supuran, C.T, Angeli, A.
Deposit date:2018-03-26
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Famotidine, an Antiulcer Agent, Strongly InhibitsHelicobacter pyloriand Human Carbonic Anhydrases.
ACS Med Chem Lett, 9, 2018
6OE1
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BU of 6oe1 by Molmil
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
Descriptor: 2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Peat, T.S.
Deposit date:2019-03-27
Release date:2019-06-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.
Eur.J.Med.Chem., 177, 2019
6G3V
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BU of 6g3v by Molmil
Crystal structure of human carbonic anhydrase I in complex with the inhibitor famotidine
Descriptor: Carbonic anhydrase 1, GLYCEROL, ZINC ION, ...
Authors:Ferraroni, M, Supuran, C.T, Angeli, A.
Deposit date:2018-03-26
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Famotidine, an Antiulcer Agent, Strongly InhibitsHelicobacter pyloriand Human Carbonic Anhydrases.
ACS Med Chem Lett, 9, 2018
1OKL
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BU of 1okl by Molmil
CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1-SULFONAMIDE
Descriptor: 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Nair, S.K, Elbaum, D, Christianson, D.W.
Deposit date:1996-06-25
Release date:1997-01-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a zinc biosensor.
J.Biol.Chem., 271, 1996
4ZWZ
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BU of 4zwz by Molmil
Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor
Descriptor: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ZINC ION, ...
Authors:Mahon, B.P, Lomelino, C.L, Driscoll, J.M, McKenna, R.
Deposit date:2015-05-19
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.
J.Med.Chem., 58, 2015

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