4RIV
A Carbonic Anhydrase IX Mimic in Complex with Saccharin
Summary for 4RIV
Entry DOI | 10.2210/pdb4riv/pdb |
Related | 4RIU |
Descriptor | Carbonic anhydrase 2, ZINC ION, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase fold, reversible hydration of co2, active site point mutations, cytosolic, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29724.76 |
Authors | Mahon, B.P.,McKenna, R. (deposition date: 2014-10-07, release date: 2015-02-04, Last modification date: 2023-09-20) |
Primary citation | Mahon, B.P.,Hendon, A.M.,Driscoll, J.M.,Rankin, G.M.,Poulsen, S.A.,Supuran, C.T.,McKenna, R. Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors. Bioorg.Med.Chem., 23:849-854, 2015 Cited by PubMed: 25614109DOI: 10.1016/j.bmc.2014.12.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.631 Å) |
Structure validation
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