6NM0
Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines
Summary for 6NM0
| Entry DOI | 10.2210/pdb6nm0/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, 4-[3-(2,4-difluorophenyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]benzene-1-sulfonamide, ... (6 entities in total) |
| Functional Keywords | breast cancer, hypoxia, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29519.61 |
| Authors | Singh, S.,McKenna, R. (deposition date: 2019-01-10, release date: 2020-01-15, Last modification date: 2023-10-11) |
| Primary citation | Mboge, M.Y.,Combs, J.,Singh, S.,Andring, J.,Wolff, A.,Tu, C.,Zhang, Z.,McKenna, R.,Frost, S.C. Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer. J.Med.Chem., 64:1713-1724, 2021 Cited by PubMed: 33523653DOI: 10.1021/acs.jmedchem.0c02077 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.44 Å) |
Structure validation
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