3HKT
Human carbonic anhydrase II in complex with alpha-D-Glucopyranosyl-(1->4)-1-thio-beta-D-glucopyranosylsulfonamide
Summary for 3HKT
Entry DOI | 10.2210/pdb3hkt/pdb |
Related | 3HKQ 3HKU |
Descriptor | Carbonic anhydrase 2, alpha-D-galactopyranose-(1-4)-(1S)-1,5-anhydro-1-sulfamoyl-D-galactitol, ZINC ION, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase drug design, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 29759.85 |
Authors | Paul, B.,Poulsen, S.-A.,Hofmann, A. (deposition date: 2009-05-25, release date: 2009-10-13, Last modification date: 2024-03-20) |
Primary citation | Lopez, M.,Paul, B.,Hofmann, A.,Morizzi, J.,Wu, Q.K.,Charman, S.A.,Innocenti, A.,Vullo, D.,Supuran, C.T.,Poulsen, S.A. S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases. J.Med.Chem., 52:6421-6432, 2009 Cited by PubMed: 19827837DOI: 10.1021/jm900914e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
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