3HKU
Human carbonic anhydrase II in complex with topiramate
Summary for 3HKU
Entry DOI | 10.2210/pdb3hku/pdb |
Related | 3HKQ 3HKT |
Descriptor | Carbonic anhydrase 2, ZINC ION, [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase drug design, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 29693.83 |
Authors | Paul, B.,Poulsen, S.-A.,Hofmann, A. (deposition date: 2009-05-25, release date: 2009-10-13, Last modification date: 2024-03-20) |
Primary citation | Lopez, M.,Paul, B.,Hofmann, A.,Morizzi, J.,Wu, Q.K.,Charman, S.A.,Innocenti, A.,Vullo, D.,Supuran, C.T.,Poulsen, S.A. S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases. J.Med.Chem., 52:6421-6432, 2009 Cited by PubMed: 19827837DOI: 10.1021/jm900914e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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