1XQ0
Structure of human carbonic anhydrase II with 4-[(3-bromo-4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole
Summary for 1XQ0
Entry DOI | 10.2210/pdb1xq0/pdb |
Related | 1XPZ |
Descriptor | Carbonic anhydrase II, ZINC ION, 2-BROMO-4-{[(4-CYANOPHENYL)(4H-1,2,4-TRIAZOL-4-YL)AMINO]METHYL}PHENYL SULFAMATE, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase, dual aromatase-steroid sulfatase inhibitor (dasi), anti-cancer drug delivery, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29737.96 |
Authors | Lloyd, M.D.,Thiyagarajan, N.,Ho, Y.T.,Woo, L.W.L.,Sutcliffe, O.B.,Purohit, A.,Reed, M.J.,Acharya, K.R.,Potter, B.V.L. (deposition date: 2004-10-11, release date: 2005-05-17, Last modification date: 2023-10-25) |
Primary citation | Lloyd, M.D.,Thiyagarajan, N.,Ho, Y.T.,Woo, L.W.L.,Sutcliffe, O.B.,Purohit, A.,Reed, M.J.,Acharya, K.R.,Potter, B.V.L. First Crystal Structures of Human Carbonic Anhydrase II in Complex with Dual Aromatase-Steroid Sulfatase Inhibitors(,) Biochemistry, 44:6858-6866, 2005 Cited by PubMed: 15865431DOI: 10.1021/bi047692e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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