1XPZ

Structure of human carbonic anhydrase II with 4-[4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole

Summary for 1XPZ

• Entry DOI: 10.2210/pdb1xpz/pdb
• Related: 1XQ0
• Descriptor: Carbonic anhydrase II, ZINC ION, 4-{[(4-CYANOPHENYL)(4H-1,2,4-TRIAZOL-4-YL)AMINO]METHYL}PHENYL SULFAMATE, ... (4 entities in total)
• Functional Keywords: carbonic anhydrase, dual aromatase-steroid sulfatase inhibitor (dasi), anti-cancer drug delivery, lyase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00918
• Total number of polymer chains: 1
• Total formula weight: 29571.99

Authors

Lloyd, M.D.,Thiyagarajan, N.,Ho, Y.T.,Woo, L.W.L.,Sutcliffe, O.B.,Purohit, A.,Reed, M.J.,Acharya, K.R.,Potter, B.V.L. (deposition date: 2004-10-11, release date: 2005-05-17, Last modification date: 2023-10-25)

• Primary citation: Lloyd, M.D.,Thiyagarajan, N.,Ho, Y.T.,Woo, L.W.L.,Sutcliffe, O.B.,Purohit, A.,Reed, M.J.,Acharya, K.R.,Potter, B.V.L.; First Crystal Structures of Human Carbonic Anhydrase II in Complex with Dual Aromatase-Steroid Sulfatase Inhibitors(,); Biochemistry, 44:6858-6866, 2005; PubMed: 15865431; DOI: 10.1021/bi047692e

Experimental method

X-RAY DIFFRACTION (2.02 Å)