8EQV
 
 | | Cryo-EM structure of PRC2 in complex with the long isoform of AEBP2 | | Descriptor: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... | | Authors: | Boudes, M, Zhang, Q, Flanigan, S.F, Davidovich, C. | | Deposit date: | 2022-10-09 | | Release date: | 2024-07-31 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | To be updated
To Be Published
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6WKR
 | | PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome | | Descriptor: | DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. | | Deposit date: | 2020-04-16 | | Release date: | 2021-02-03 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.
Science, 371, 2021
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8FYH
 | | G4 RNA-mediated PRC2 dimer | | Descriptor: | G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ... | | Authors: | Song, J, Kasinath, V. | | Deposit date: | 2023-01-26 | | Release date: | 2023-10-04 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Science, 381, 2023
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7AT8
 | | Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2. | | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3.2, ... | | Authors: | Finogenova, K, Benda, C, Schaefer, I.B, Poepsel, S, Strauss, M, Mueller, J. | | Deposit date: | 2020-10-29 | | Release date: | 2020-12-09 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3.
Elife, 9, 2020
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7TD5
 | | Structure of human PRC2-EZH1 containing phosphorylated SUZ12 | | Descriptor: | Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, Polycomb protein SUZ12, ... | | Authors: | Gong, L, Jiao, L, Liu, X. | | Deposit date: | 2021-12-30 | | Release date: | 2022-11-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.994 Å) | | Cite: | CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site.
Nat Commun, 13, 2022
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6KIX
 | | Cryo-EM structure of human MLL1-NCP complex, binding mode1 | | Descriptor: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | | Authors: | Huang, J, Xue, H, Yao, T. | | Deposit date: | 2019-07-20 | | Release date: | 2019-09-11 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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6KIV
 | | Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) | | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Huang, J, Xue, H, Yao, T. | | Deposit date: | 2019-07-20 | | Release date: | 2019-09-11 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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6KIU
 | | Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) | | Descriptor: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | | Authors: | Huang, J, Xue, H, Yao, T. | | Deposit date: | 2019-07-20 | | Release date: | 2019-09-11 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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6KIZ
 | | Cryo-EM structure of human MLL1-NCP complex, binding mode2 | | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Huang, J, Xue, H, Yao, T. | | Deposit date: | 2019-07-20 | | Release date: | 2019-09-11 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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7UD5
 | | Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome | | Descriptor: | 601 DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Niklas, H.A, Rahman, S, Worden, E.J, Wolberger, C. | | Deposit date: | 2022-03-18 | | Release date: | 2022-09-21 | | Last modified: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (4.25 Å) | | Cite: | Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6KIW
 | | Cryo-EM structure of human MLL3-ubNCP complex (4.0 angstrom) | | Descriptor: | DNA (144-MER), DNA (145-MER), Histone H2A, ... | | Authors: | Huang, J, Xue, H, Yao, T. | | Deposit date: | 2019-07-20 | | Release date: | 2019-09-11 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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8SWI
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8SR6
 | | Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3 (3-17)peptide | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Eukaryotic huntingtin interacting protein B, ... | | Authors: | Xu, C, Chung, I.Y.W, Cygler, M. | | Deposit date: | 2023-05-05 | | Release date: | 2024-03-13 | | Last modified: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin.
Mbio, 14, 2023
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5KJH
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5KKL
 | | Structure of ctPRC2 in complex with H3K27me3 and H3K27M | | Descriptor: | ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA, Putative uncharacterized protein,Histone H3.1 peptide,Zinc finger domain-containing protein, S-ADENOSYLMETHIONINE, ... | | Authors: | Jiao, L, Liu, X. | | Deposit date: | 2016-06-21 | | Release date: | 2017-04-19 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016
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8T9F
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8T9H
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5KJI
 | | Crystal structure of an active polycomb repressive complex 2 in the basal state | | Descriptor: | Putative uncharacterized protein,Zinc finger domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | | Authors: | Jiao, L, Liu, X. | | Deposit date: | 2016-06-20 | | Release date: | 2017-04-19 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016
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8T9G
 | | Automethylated PRC2 dimer bound to nucleosome | | Descriptor: | DNA (226-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Sauer, P.V, Pavlenko, E, Nogales, E, Poepsel, S. | | Deposit date: | 2023-06-23 | | Release date: | 2024-09-25 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Activation of automethylated PRC2 by dimerization on chromatin.
Mol.Cell, 84, 2024
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8TB9
 | | PRC2-J119-450 monomer bound to H1-nucleosome | | Descriptor: | DNA (226-MER), Histone H1.0, Histone H2A type 1, ... | | Authors: | Sauer, P.V, Cookis, T, Pavlenko, E, Nogales, E, Poepsel, S. | | Deposit date: | 2023-06-28 | | Release date: | 2024-09-25 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Activation of automethylated PRC2 by dimerization on chromatin.
Mol.Cell, 84, 2024
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8TAS
 | | PRC2 monomer bound to nucleosome | | Descriptor: | DNA (226-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Sauer, P.V, Pavlenko, E, Nogales, E, Poepsel, S. | | Deposit date: | 2023-06-27 | | Release date: | 2024-09-25 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Activation of automethylated PRC2 by dimerization on chromatin.
Mol.Cell, 84, 2024
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8W9Z
 | | The cryo-EM structure of the Nicotiana tabacum PEP-PAP | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta'', ... | | Authors: | Wu, X.X, Zhang, Y. | | Deposit date: | 2023-09-06 | | Release date: | 2024-03-13 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structures of the plant plastid-encoded RNA polymerase.
Cell, 187, 2024
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8WA1
 | | The cryo-EM structure of the Nicotiana tabacum PEP-PAP-TEC2 | | Descriptor: | DNA (24-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Wu, X.X, Zhang, Y. | | Deposit date: | 2023-09-06 | | Release date: | 2024-03-13 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structures of the plant plastid-encoded RNA polymerase.
Cell, 187, 2024
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8WA0
 | | The cryo-EM structure of the Nicotiana tabacum PEP-PAP-TEC1 | | Descriptor: | DNA (48-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Wu, X.X, Zhang, Y. | | Deposit date: | 2023-09-06 | | Release date: | 2024-03-13 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Cryo-EM structures of the plant plastid-encoded RNA polymerase.
Cell, 187, 2024
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9C8U
 | | Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min | | Descriptor: | Isoform 2 of Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ... | | Authors: | Abe, K.M, Li, G, He, Q, Grant, T, Lim, C. | | Deposit date: | 2024-06-13 | | Release date: | 2024-09-04 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min
To Be Published
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