5ABJ
 
 | | Structure of Coxsackievirus A16 in complex with GPP3 | | Descriptor: | 1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE, CHLORIDE ION, SODIUM ION, ... | | Authors: | De Colibus, L, Wang, X, Tijsma, A, Neyts, J, Spyrou, J.A.B, Ren, J, Grimes, J.M, Puerstinger, G, Leyssen, P, Fry, E.E, Rao, Z, Stuart, D.I. | | Deposit date: | 2015-08-06 | | Release date: | 2015-09-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structure Elucidation of Coxsackievirus A16 in Complex with Gpp3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses.
Plos Pathog., 11, 2015
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5AAA
 | | Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib | | Descriptor: | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, ALK TYROSINE KINASE RECEPTOR | | Authors: | McTigue, M, Deng, Y, Liu, W, Brooun, A, Stewart, A. | | Deposit date: | 2015-07-23 | | Release date: | 2016-06-08 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F.
N.Engl.J.Med., 374, 2016
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2B9D
 | | Crystal Structure of HPV E7 CR3 domain | | Descriptor: | E7 protein, ZINC ION | | Authors: | Liu, X, Clements, A, Zhao, K, Marmorstein, R. | | Deposit date: | 2005-10-11 | | Release date: | 2005-10-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor.
J.Biol.Chem., 281, 2006
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1Q09
 | | Crystal structure of the Zn(II) form of E. coli ZntR, a zinc-sensing transcriptional regulator (space group I4122) | | Descriptor: | SULFATE ION, ZINC ION, Zn(II)-responsive regulator of zntA | | Authors: | Changela, A, Chen, K, Xue, Y, Holschen, J, Outten, C.E, O'Halloran, T.V, Mondragon, A. | | Deposit date: | 2003-07-15 | | Release date: | 2003-09-16 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR
Science, 301, 2003
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3DLK
 | | Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A | | Descriptor: | Reverse transcriptase/ribonuclease H, SULFATE ION, p51 RT | | Authors: | Ho, W.C, Bauman, J.D, Himmel, D.M, Das, K, Arnold, E. | | Deposit date: | 2008-06-27 | | Release date: | 2008-10-07 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.
Nucleic Acids Res., 36, 2008
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2CUE
 | | Solution structure of the homeobox domain of the human paired box protein Pax-6 | | Descriptor: | Paired box protein Pax6 | | Authors: | Ohnishi, S, Kigawa, T, Tochio, N, Tomizawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-26 | | Release date: | 2005-11-26 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the homeobox domain of the human paired box protein Pax-6
To be Published
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1ZKG
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1Z77
 | | Crystal structure of transcriptional regulator protein from Thermotoga maritima. | | Descriptor: | 1,2-ETHANEDIOL, transcriptional regulator (TetR family) | | Authors: | Koclega, K.D, Chruszcz, M, Zimmerman, M.D, Cymborowski, M, Kudritska, M, Minor, W, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2005-03-24 | | Release date: | 2005-05-10 | | Last modified: | 2022-04-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment.
J.Struct.Biol., 159, 2007
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3WJ4
 | | Crystal structure of PPARgamma ligand binding domain in complex with tributyltin | | Descriptor: | Peroxisome proliferator-activated receptor gamma, tributylstannanyl | | Authors: | Harada, S, Hiromori, Y, Fukakusa, S, Kawahara, K, Nakamura, S, Noda, M, Uchiyama, S, Fukui, K, Nishikawa, J, Nagase, H, Kobayashi, Y, Ohkubo, T, Yoshida, T, Nakanishi, T. | | Deposit date: | 2013-10-04 | | Release date: | 2014-10-15 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural basis for PPARgamma transactivation by endocrine disrupting organotin compounds
To be Published
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3N43
 | | Crystal structures of the mature envelope glycoprotein complex (trypsin cleavage) of Chikungunya virus. | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | Authors: | Voss, J, Vaney, M.C, Duquerroy, S, Rey, F.A. | | Deposit date: | 2010-05-21 | | Release date: | 2010-12-01 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography.
Nature, 468, 2010
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3FEI
 | | Design and biological evaluation of novel, balanced dual PPARa/g agonists | | Descriptor: | (2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid, Peptide motif 5 of Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor alpha | | Authors: | Benz, J, Grether, U, Gsell, B, Binggeli, A, Hilpert, H, Maerki, H.P, Mohr, P, Ruf, A, Stihle, M, Schlatter, D. | | Deposit date: | 2008-11-30 | | Release date: | 2009-10-20 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists
Chemmedchem, 4, 2009
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3NM8
 | | Crystal structure of Tyrosinase from Bacillus megaterium | | Descriptor: | CHLORIDE ION, COPPER (II) ION, Tyrosinase, ... | | Authors: | Sendovski, M, Kanteev, M, Adir, N, Fishman, A. | | Deposit date: | 2010-06-22 | | Release date: | 2010-11-17 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | First structures of an active bacterial tyrosinase reveal copper plasticity
J.Mol.Biol., 405, 2011
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3N1N
 | | Crystal structure of the complex of type I ribosome inactivating protein with guanine at 2.2A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GUANINE, Ribosome inactivating protein | | Authors: | Kushwaha, G.S, Singh, N, Sinha, M, Kaur, P, Betzel, C, Sharma, S, Singh, T.P. | | Deposit date: | 2010-05-16 | | Release date: | 2010-07-14 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Crystal structures of a type-1 ribosome inactivating protein from Momordica balsamina in the bound and unbound states
Biochim.Biophys.Acta, 1824, 2012
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3N2C
 | | Crystal structure of prolidase eah89906 complexed with n-methylphosphonate-l-proline | | Descriptor: | 1-[(R)-hydroxy(methyl)phosphoryl]-L-proline, PROLIDASE, ZINC ION | | Authors: | Patskovsky, Y, Xu, C, Sauder, J.M, Burley, S.K, Raushel, F.M, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2010-05-17 | | Release date: | 2010-06-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Functional identification and structure determination of two novel prolidases from cog1228 in the amidohydrolase superfamily .
Biochemistry, 49, 2010
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3N5L
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3NEQ
 | | Crystal structure of the chimeric muscarinic toxin MT7 with loop 3 from MT1 | | Descriptor: | SULFATE ION, Three-finger muscarinic toxin 7 | | Authors: | Stura, E.A, Servent, D, Menez, R, Mournier, G, Menez, A, Fruchart-Gaillard, C. | | Deposit date: | 2010-06-09 | | Release date: | 2011-08-24 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.
Plos One, 7, 2012
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3NE7
 | | Crystal structure of paia n-acetyltransferase from thermoplasma acidophilum in complex with coenzyme a | | Descriptor: | ACETYLTRANSFERASE, BETA-MERCAPTOETHANOL, COENZYME A, ... | | Authors: | Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Clancy, S, Joachimiak, A, Anderson, F.W, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2010-06-08 | | Release date: | 2010-07-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production.
Proteins, 79, 2011
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3N5U
 | | Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1 | | Descriptor: | CHLORIDE ION, MANGANESE (II) ION, Retinoblastoma-associated protein, ... | | Authors: | Hirschi, A.M, Cecchini, M, Steinhardt, R.C, Dick, F.A, Rubin, S.M. | | Deposit date: | 2010-05-25 | | Release date: | 2010-08-11 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein.
Nat.Struct.Mol.Biol., 17, 2010
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3NN2
 | | Structure of chlorite dismutase from Candidatus Nitrospira defluvii in complex with cyanide | | Descriptor: | CYANIDE ION, Chlorite dismutase, GLYCEROL, ... | | Authors: | Kostan, J, Sjoeblom, B, Maixner, F, Mlynek, G, Furtmueller, P.G, Obinger, C, Wagner, M, Daims, H, Djinovic-Carugo, K. | | Deposit date: | 2010-06-23 | | Release date: | 2010-07-28 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Structural and functional characterisation of the chlorite dismutase from the nitrite-oxidizing bacterium "Candidatus Nitrospira defluvii": Identification of a catalytically important amino acid residue
J.Struct.Biol., 172, 2010
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3NI7
 | | Crystal structure of the TetR transcriptional regulator from Nitrosomonas europaea ATCC 19718 | | Descriptor: | Bacterial regulatory proteins, TetR family | | Authors: | Knapik, A, Chruszcz, M, Cymborowski, M, Xu, X, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2010-06-15 | | Release date: | 2010-08-11 | | Last modified: | 2022-04-13 | | Method: | X-RAY DIFFRACTION (2.78 Å) | | Cite: | Crystal structure of the TetR transcriptional regulator from Nitrosomonas europaea ATCC 19718
To be Published
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3NN1
 | | Structure of chlorite dismutase from Candidatus Nitrospira defluvii in complex with imidazole | | Descriptor: | 1,2-ETHANEDIOL, Chlorite dismutase, IMIDAZOLE, ... | | Authors: | Kostan, J, Sjoeblom, B, Maixner, F, Mlynek, G, Furtmueller, P.G, Obinger, C, Wagner, M, Daims, H, Djinovic-Carugo, K. | | Deposit date: | 2010-06-23 | | Release date: | 2010-07-28 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural and functional characterisation of the chlorite dismutase from the nitrite-oxidizing bacterium "Candidatus Nitrospira defluvii": Identification of a catalytically important amino acid residue
J.Struct.Biol., 172, 2010
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3N6V
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3N9O
 | | ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K9me2 peptide and NOG | | Descriptor: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | | Authors: | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | | Deposit date: | 2010-05-31 | | Release date: | 2010-06-30 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.309 Å) | | Cite: | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
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3KDF
 | | X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression | | Descriptor: | 1,2-ETHANEDIOL, Replication protein A 14 kDa subunit, Replication protein A 32 kDa subunit | | Authors: | Burgie, E.S, Bingman, C.A, Phillips Jr, G.N, Fox, B.G, Makino, S.-I, Center for Eukaryotic Structural Genomics (CESG) | | Deposit date: | 2009-10-22 | | Release date: | 2009-12-01 | | Last modified: | 2021-10-13 | | Method: | X-RAY DIFFRACTION (1.975 Å) | | Cite: | X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression
To be Published
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3N9P
 | | ceKDM7A from C.elegans, complex with H3K4me3K27me2 peptide and NOG | | Descriptor: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | | Authors: | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | | Deposit date: | 2010-05-31 | | Release date: | 2010-06-30 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.388 Å) | | Cite: | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
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