1Z77
Crystal structure of transcriptional regulator protein from Thermotoga maritima.
Summary for 1Z77
| Entry DOI | 10.2210/pdb1z77/pdb |
| Descriptor | transcriptional regulator (TetR family), 1,2-ETHANEDIOL (3 entities in total) |
| Functional Keywords | transcriptional regulator, tetr family, structural genomics, psi, protein structure initiative, midwest center for structural genomics, mcsg, transcription |
| Biological source | Thermotoga maritima |
| Total number of polymer chains | 1 |
| Total formula weight | 24338.01 |
| Authors | Koclega, K.D.,Chruszcz, M.,Zimmerman, M.D.,Cymborowski, M.,Kudritska, M.,Minor, W.,Midwest Center for Structural Genomics (MCSG) (deposition date: 2005-03-24, release date: 2005-05-10, Last modification date: 2024-11-20) |
| Primary citation | Koclega, K.D.,Chruszcz, M.,Zimmerman, M.D.,Cymborowski, M.,Evdokimova, E.,Minor, W. Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment. J.Struct.Biol., 159:424-432, 2007 Cited by PubMed Abstract: The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained. PubMed: 17588774DOI: 10.1016/j.jsb.2007.04.012 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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