PDB: 4050 resultsInfo pagesStatus searchChemie searchBIRD

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4BXS	Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Lechtenberg, B.C, Murray-Rust, T.A, Johnson, D.J.D, Adams, T.E, Krishnaswamy, S, Camire, R.M, Huntington, J.A. Deposit date: 2013-07-15 Release date: 2013-07-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis. Blood, 122, 2013
1VJA	Urokinase Plasminogen Activator B-Chain-JT463 Complex Descriptor: N-(BENZYLSULFONYL)SERYL-N~1~-{4-[(Z)-AMINO(IMINO)METHYL]BENZYL}SERINAMIDE, SULFATE ION, plasminogen activator, ... Authors: Schweinitz, A, Steinmetzer, T, Banke, I.J, Arlt, M.J.E, Stuerzebecher, A, Schuster, O, Geissler, A, Giersiefen, H, Zeslawska, E, Jacob, U, Kruger, A, Stuerzebecher, J. Deposit date: 2004-02-03 Release date: 2004-06-22 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents J.Biol.Chem., 279, 2004
4DUR	The X-ray Crystal Structure of Full-Length type II Human Plasminogen Descriptor: ACETATE ION, BICARBONATE ION, CHLORIDE ION, ... Authors: Law, R.H.P, Caradoc-Davies, T, Whisstock, J.C. Deposit date: 2012-02-22 Release date: 2012-03-28 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.45 Å) Cite: The X-ray crystal structure of full-length human plasminogen Cell Rep, 1, 2012
4DUU	The X-ray Crystal Structure of Full-Length type I Human Plasminogen Descriptor: Plasminogen Authors: Law, R.H.P, Caradoc-Davies, T, Whisstock, J.C. Deposit date: 2012-02-22 Release date: 2012-03-28 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (5.2 Å) Cite: The X-ray crystal structure of full-length human plasminogen Cell Rep, 1, 2012
4DII	X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of potassium ions Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... Authors: Russo Krauss, I, Merlino, A, Mazzarella, L, Sica, F. Deposit date: 2012-01-31 Release date: 2012-07-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity. Nucleic Acids Res., 40, 2012
1YCP	THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16 Descriptor: ALPHA THROMBIN, EPSILON THROMBIN, FIBRINOPEPTIDE A-ALPHA Authors: Malkowski, M.G, Edwards, B.F.P. Deposit date: 1997-05-01 Release date: 1998-05-06 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16. Biochem.J., 326, 1997
6FHP	DAIP in complex with a C-terminal fragment of thermolysin Descriptor: Dispase autolysis-inducing protein, Thermolysin Authors: Schmelz, S, Fiebig, D, Fuchsbauer, H.L, Blankenfeldt, W, Scrima, A. Deposit date: 2018-01-15 Release date: 2018-09-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.703 Å) Cite: Destructive twisting of neutral metalloproteases: the catalysis mechanism of the Dispase autolysis-inducing protein from Streptomyces mobaraensis DSM 40487. FEBS J., 285, 2018
3OX7	The crystal structure of uPA complex with peptide inhibitor MH027 at pH4.6 Descriptor: MH027, SULFATE ION, TETRAETHYLENE GLYCOL, ... Authors: Jiang, L.G, Andreasen, P.A, Huang, M.D. Deposit date: 2010-09-21 Release date: 2011-08-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.58 Å) Cite: The binding mechanism of a peptidic cyclic serine protease inhibitor J.Mol.Biol., 412, 2011
3PMA	2.2 Angstrom crystal structure of the complex between Bovine Thrombin and Sucrose Octasulfate Descriptor: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CITRIC ACID, SODIUM ION, ... Authors: Wright, H.T, Scarsdale, J.N, Desai, B.J. Deposit date: 2010-11-16 Release date: 2011-07-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Interaction of thrombin with sucrose octasulfate. Biochemistry, 50, 2011
3PMH	Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, Platelet glycoprotein Ib alpha chain, ... Authors: Varughese, K.I, Celikel, R. Deposit date: 2010-11-16 Release date: 2011-06-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I. Proc.Natl.Acad.Sci.USA, 108, 2011
3PRO	ALPHA-LYTIC PROTEASE COMPLEXED WITH C-TERMINAL TRUNCATED PRO REGION Descriptor: 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, ALPHA-LYTIC PROTEASE Authors: Sauter, N.K, Mau, T, Rader, S.D, Agard, D.A. Deposit date: 1998-08-26 Release date: 1999-04-27 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of alpha-lytic protease complexed with its pro region. Nat.Struct.Biol., 5, 1998
3PMB	2.9 Angstrom crystal structure of bovine thrombin in tetragonal spacegroup Descriptor: SODIUM ION, Thrombin heavy chain, Thrombin light chain Authors: Wright, H.T, Scarsdale, J.N, Desai, B.J. Deposit date: 2010-11-16 Release date: 2011-07-20 Last modified: 2011-08-24 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Interaction of thrombin with sucrose octasulfate. Biochemistry, 50, 2011
3Q3K	Factor Xa in complex with a phenylenediamine derivative Descriptor: Activated factor Xa heavy chain, CALCIUM ION, Factor X light chain, ... Authors: Suzuki, M, Imai, E. Deposit date: 2010-12-22 Release date: 2011-12-28 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
3OY6	The crystal structure of uPA complex with peptide inhibitor MH036 at pH4.6 Descriptor: MH036, Urokinase-type plasminogen activator Authors: Jiang, L.G, Andreasen, P.A, Huang, M.D. Deposit date: 2010-09-22 Release date: 2011-08-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.31 Å) Cite: The binding mechanism of a peptidic cyclic serine protease inhibitor J.Mol.Biol., 412, 2011
3OY5	The crystal structure of uPA complex with peptide inhibitor MH027 at pH7.4 Descriptor: MH027, SULFATE ION, Urokinase-type plasminogen activator Authors: Jiang, L.G, Andreasen, P.A, Huang, M.D. Deposit date: 2010-09-22 Release date: 2011-08-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.31 Å) Cite: The binding mechanism of a peptidic cyclic serine protease inhibitor J.Mol.Biol., 412, 2011
3QLP	X-ray structure of the complex between human alpha thrombin and a modified thrombin binding aptamer (mTBA) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, POTASSIUM ION, ... Authors: Russo Krauss, I, Merlino, A, Mazzarella, L, Sica, F. Deposit date: 2011-02-03 Release date: 2011-10-19 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Thrombin-aptamer recognition: a revealed ambiguity. Nucleic Acids Res., 39, 2011
3QTV	Thrombin Inhibition by Pyridin Derivatives Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(1-methylpyridinium-4-yl)methyl]-L-prolinamide, GLYCEROL, ... Authors: Biela, A, Heine, A, Klebe, G. Deposit date: 2011-02-23 Release date: 2012-02-29 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Impact of ligand and protein desolvation on ligand binding to the S1 pocket of thrombin J.Mol.Biol., 418, 2012
3QWC	Thrombin Inhibition by Pyridin Derivatives Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(4-chloro-1-methylpyridinium-3-yl)methyl]-L-prolinamide, GLYCEROL, ... Authors: Biela, A, Heine, A, Klebe, G. Deposit date: 2011-02-28 Release date: 2012-03-14 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Impact of ligand and protein desolvation on ligand binding to the S1 pocket of thrombin J.Mol.Biol., 418, 2012
3QX5	Thrombin Inhibition by Pyridin Derivatives Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(4-chloro-1-methylpyridinium-2-yl)methyl]-L-prolinamide, GLYCEROL, ... Authors: Biela, A, Heine, A, Klebe, G. Deposit date: 2011-03-01 Release date: 2012-03-07 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Impact of ligand and protein desolvation on ligand binding to the S1 pocket of thrombin J.Mol.Biol., 418, 2012
3QUM	Crystal structure of human prostate specific antigen (PSA) in Fab sandwich with a high affinity and a PCa selective antibody Descriptor: Fab 5D3D11 Heavy Chain, Fab 5D3D11 Light Chain, Fab 5D5A5 Heavy Chain, ... Authors: Stura, E.A, Muller, B.H, Michel, S, Ducancel, F. Deposit date: 2011-02-24 Release date: 2011-11-09 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of human prostate-specific antigen in a sandwich antibody complex. J.Mol.Biol., 414, 2011
3RLW	Human Thrombin in complex with MI328 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hirudin variant-2, ... Authors: Biela, A, Heine, A, Klebe, G. Deposit date: 2011-04-20 Release date: 2012-04-25 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect J.Med.Chem., 55, 2012
3RMO	Human Thrombin in complex with MI004 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hirudin variant-2, ... Authors: Biela, A, Heine, A, Klebe, G. Deposit date: 2011-04-21 Release date: 2012-04-25 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect J.Med.Chem., 55, 2012
3P17	Thrombin Inhibition by Pyridin Derivatives Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-(pyridin-3-ylmethyl)-L-prolinamide, Hirudin variant-2, ... Authors: Biela, A, Heine, A, Klebe, G. Deposit date: 2010-09-30 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Impact of ligand and protein desolvation on ligand binding to the S1 pocket of thrombin. J.Mol.Biol., 418, 2012
3RMM	Human Thrombin in complex with MI332 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hirudin variant-2, ... Authors: Biela, A, Heine, A, Klebe, G. Deposit date: 2011-04-21 Release date: 2012-04-25 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect J.Med.Chem., 55, 2012
3RM2	Human Thrombin in complex with MI003 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hirudin variant-2, ... Authors: Biela, A, Heine, A, Klebe, G. Deposit date: 2011-04-20 Release date: 2012-04-25 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.23 Å) Cite: Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect J.Med.Chem., 55, 2012

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