1VJA

Urokinase Plasminogen Activator B-Chain-JT463 Complex

Summary for 1VJA

Entry DOI	10.2210/pdb1vja/pdb
Related	1F5K 1F5L 1F92 1SC8 1VJ9
Descriptor	plasminogen activator, urokinase, SULFATE ION, N-(BENZYLSULFONYL)SERYL-N~1~-{4-[(Z)-AMINO(IMINO)METHYL]BENZYL}SERINAMIDE, ... (4 entities in total)
Functional Keywords	urokinase, inhibitor, serine protease, human, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00749
Total number of polymer chains	1
Total formula weight	30353.61
Authors	Schweinitz, A.,Steinmetzer, T.,Banke, I.J.,Arlt, M.J.E.,Stuerzebecher, A.,Schuster, O.,Geissler, A.,Giersiefen, H.,Zeslawska, E.,Jacob, U.,Kruger, A.,Stuerzebecher, J. (deposition date: 2004-02-03, release date: 2004-06-22, Last modification date: 2023-08-23)
Primary citation	Schweinitz, A.,Steinmetzer, T.,Banke, I.J.,Arlt, M.J.E.,Stuerzebecher, A.,Schuster, O.,Geissler, A.,Giersiefen, H.,Zeslawska, E.,Jacob, U.,Kruger, A.,Stuerzebecher, J. Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents J.Biol.Chem., 279:33613-33622, 2004 Cited by PubMed: 15150279 DOI: 10.1074/jbc.M314151200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation