3QUM

Crystal structure of human prostate specific antigen (PSA) in Fab sandwich with a high affinity and a PCa selective antibody

Summary for 3QUM

• Entry DOI: 10.2210/pdb3qum/pdb
• Related: 2ZCH 2ZCK 2ZCL
• Related PRD ID: PRD_900084
• Descriptor: Prostate-specific antigen, Fab 5D3D11 Light Chain, Fab 5D3D11 Heavy Chain, ... (9 entities in total)
• Functional Keywords: kallikrein fold, prostate-specific antigen, serine protease, negative regulation of angiogenesis, natural post-transductional modification, n-linked and o-linked glycosylation, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P07288
• Total number of polymer chains: 10
• Total formula weight: 249837.88

Authors

Stura, E.A.,Muller, B.H.,Michel, S.,Ducancel, F. (deposition date: 2011-02-24, release date: 2011-11-09, Last modification date: 2023-09-13)

• Primary citation: Stura, E.A.,Muller, B.H.,Bossus, M.,Michel, S.,Jolivet-Reynaud, C.,Ducancel, F.; Crystal structure of human prostate-specific antigen in a sandwich antibody complex.; J.Mol.Biol., 414:530-544, 2011; PubMed: 22037582; DOI: 10.1016/j.jmb.2011.10.007

Experimental method

X-RAY DIFFRACTION (3.2 Å)