3QUM

Crystal structure of human prostate specific antigen (PSA) in Fab sandwich with a high affinity and a PCa selective antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0002803	biological_process	positive regulation of antibacterial peptide production
P	0003073	biological_process	regulation of systemic arterial blood pressure
P	0004175	molecular_function	endopeptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0006508	biological_process	proteolysis
P	0008233	molecular_function	peptidase activity
P	0008236	molecular_function	serine-type peptidase activity
P	0016525	biological_process	negative regulation of angiogenesis
P	0016787	molecular_function	hydrolase activity
P	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
P	0030141	cellular_component	secretory granule
P	0031638	biological_process	zymogen activation
P	0032991	cellular_component	protein-containing complex
P	0070062	cellular_component	extracellular exosome
Q	0002803	biological_process	positive regulation of antibacterial peptide production
Q	0003073	biological_process	regulation of systemic arterial blood pressure
Q	0004175	molecular_function	endopeptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005634	cellular_component	nucleus
Q	0006508	biological_process	proteolysis
Q	0008233	molecular_function	peptidase activity
Q	0008236	molecular_function	serine-type peptidase activity
Q	0016525	biological_process	negative regulation of angiogenesis
Q	0016787	molecular_function	hydrolase activity
Q	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Q	0030141	cellular_component	secretory granule
Q	0031638	biological_process	zymogen activation
Q	0032991	cellular_component	protein-containing complex
Q	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
P	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. STcsGDSGGPLV

Chain	Residue	Details
P	SER189-VAL200

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
A	TYR192-HIS198
L	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	466
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"18187150","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

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