3QUM
Crystal structure of human prostate specific antigen (PSA) in Fab sandwich with a high affinity and a PCa selective antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F (P, Q) | Prostate-specific antigen | polymer | 237 | 26122.0 | 2 | UniProt (P07288) Pfam (PF00089) | Homo sapiens (human) | PSA, Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase |
| 2 | B, G (L, M) | Fab 5D3D11 Light Chain | polymer | 219 | 24272.0 | 2 | Mus musculus | ||
| 3 | C, H (H, K) | Fab 5D3D11 Heavy Chain | polymer | 219 | 23551.4 | 2 | Mus musculus | ||
| 4 | D, I (A, C) | Fab 5D5A5 Light Chain | polymer | 218 | 24189.7 | 2 | Mus musculus | ||
| 5 | E, J (B, D) | Fab 5D5A5 Heavy Chain | polymer | 219 | 23565.4 | 2 | Mus musculus | ||
| 6 | K (E) | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-[N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 3026.7 | 1 | In PDB GlyTouCan (G87655FC) | |||
| 7 | L (F) | beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose | branched | 383.3 | 1 | In PDB BIRD (PRD_900084) GlyTouCan (G00031MO) | Thomsen-Friedenreich antigen | ||
| 8 | M (G) | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 3026.7 | 1 | In PDB GlyTouCan (G67371LF) | |||
| 9 | N, O, P, Q, R... (P, L, H, A, B...) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 243401.1 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 6436.8 | |
| All* | Total formula weight | 249837.9 |
