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4DII

X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of potassium ions

Summary for 4DII
Entry DOI10.2210/pdb4dii/pdb
Related4DIH
Related PRD IDPRD_000020
DescriptorProthrombin, Thrombin binding aptamer, ZINC ION, ... (10 entities in total)
Functional Keywordsprotein-dna complex, serine protease, blood coagulation, aptamer, hydrolase-hydrolase inhibitor-dna complex, serine protease fold, dna aptamer, blood, g-quadruplex, hydrolase/hydrolase inhibitor/dna
Biological sourceHomo sapiens (human)
More
Total number of polymer chains3
Total formula weight39558.81
Authors
Russo Krauss, I.,Merlino, A.,Mazzarella, L.,Sica, F. (deposition date: 2012-01-31, release date: 2012-07-18, Last modification date: 2023-09-13)
Primary citationRusso Krauss, I.,Merlino, A.,Randazzo, A.,Novellino, E.,Mazzarella, L.,Sica, F.
High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity.
Nucleic Acids Res., 40:8119-8128, 2012
Cited by
PubMed: 22669903
DOI: 10.1093/nar/gks512
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.05 Å)
Structure validation

217705

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