4DIH
X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of sodium ions
Summary for 4DIH
Entry DOI | 10.2210/pdb4dih/pdb |
Related | 4DII |
Related PRD ID | PRD_000020 |
Descriptor | Prothrombin, Thrombin binding aptamer, ZINC ION, ... (9 entities in total) |
Functional Keywords | protein-dna complex, serine protease, blood coagulation, aptamer, hydrolase-hydrolase inhibitor-dna complex, serine protease fold, dna aptamer, blood, g-quadruplex, hydrolase/hydrolase inhibitor/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 39608.11 |
Authors | Russo Krauss, I.,Merlino, A.,Mazzarella, L.,Sica, F. (deposition date: 2012-01-31, release date: 2012-07-18, Last modification date: 2023-09-13) |
Primary citation | Russo Krauss, I.,Merlino, A.,Randazzo, A.,Novellino, E.,Mazzarella, L.,Sica, F. High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity. Nucleic Acids Res., 40:8119-8128, 2012 Cited by PubMed: 22669903DOI: 10.1093/nar/gks512 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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