7V0P
| Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a potently neutralizing human antibody IgG-106 | Descriptor: | IgG 106 Fab heavy chain, IgG 106 Fab light chain, Spike glycoprotein E1, ... | Authors: | Bandyopadhyay, A, Klose, T, Kuhn, R.J. | Deposit date: | 2022-05-10 | Release date: | 2023-04-05 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 120, 2023
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7TGF
| Single-domain VHH intrabodies neutralize ricin toxin. | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin chain A, ... | Authors: | Rudolph, M.J, Mantis, N. | Deposit date: | 2022-01-07 | Release date: | 2022-10-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.347 Å) | Cite: | Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins. J.Biol.Chem., 298, 2022
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7K22
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7K23
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7K25
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7K24
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7MXE
| Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8ANC195 G52K5 Fab heavy chain, ... | Authors: | Abernathy, M.E, Bjorkman, P.J. | Deposit date: | 2021-05-19 | Release date: | 2021-10-27 | Last modified: | 2021-11-03 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope. Npj Vaccines, 6, 2021
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5J57
| V5E1-RTA complex | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin, ... | Authors: | Rudolph, M.J. | Deposit date: | 2016-04-01 | Release date: | 2016-12-07 | Last modified: | 2019-12-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin's Enzymatic Subunit. J. Biol. Chem., 292, 2017
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7ZWF
| Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3 | Descriptor: | 32F3scFv, Gametocyte surface protein P45/48, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | Deposit date: | 2022-05-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.132 Å) | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies. Nat Commun, 13, 2022
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8E1G
| SARS-CoV-2 RBD in complex with Omicron-neutralizing antibody 2A10 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2A10 Fab, heavy chain, ... | Authors: | Wasserman, H, Hastie, K.M, Buck, T.K, Saphire, E.O. | Deposit date: | 2022-08-10 | Release date: | 2023-06-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence. Cell Rep, 42, 2023
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5TP3
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6CDE
| Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ... | Authors: | Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D. | Deposit date: | 2018-02-08 | Release date: | 2018-05-16 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018
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7D3L
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6XRJ
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5E1H
| Ricin toxin in complex with neutralizing single chain monoclonal antibodies (VHHs) | Descriptor: | CHLORIDE ION, F8(JOB10) VHH antibody, Ricin | Authors: | Rudolph, M.J, Vance, D, Shoemaker, C, Mantis, N. | Deposit date: | 2015-09-29 | Release date: | 2016-08-03 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.032 Å) | Cite: | Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit. Proteins, 84, 2016
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7D3M
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7D3K
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8F0I
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7MEP
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7M30
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4HFW
| Anti Rotavirus Antibody | Descriptor: | 6-26 Fab Heavy chain, 6-26 Fab Light chain, SULFATE ION | Authors: | Spiller, B.W, Aiyegbo, M, Crowe, J.E. | Deposit date: | 2012-10-05 | Release date: | 2013-05-29 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore. Plos One, 8, 2013
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7LM8
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8CZ8
| Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics | Descriptor: | Mesothelin, cleaved form, SULFATE ION, ... | Authors: | Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E. | Deposit date: | 2022-05-24 | Release date: | 2023-06-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3, 2023
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8SGU
| Crystal structure of the SARS-CoV-2 receptor binding domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Sankhala, R.S, Jensen, J.L, Joyce, M.G. | Deposit date: | 2023-04-13 | Release date: | 2023-12-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain. Structure, 32, 2024
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6CDI
| Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ... | Authors: | Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D. | Deposit date: | 2018-02-08 | Release date: | 2018-05-16 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018
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