8CZ8

Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics

Summary for 8CZ8

• Entry DOI: 10.2210/pdb8cz8/pdb
• Descriptor: scFv Anetumab, Mesothelin, cleaved form, scFv of A12 anti-mesothelin antibody, ... (5 entities in total)
• Functional Keywords: antibody, complex, tumor associated antigen, antitumor protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 137586.37

Authors

Bandaranayake, A.D.,Rupert, P.B.,Lin, I.,Pilat, K.,Ruff, R.O.,Friend, D.J.,Chan, M.K.,Clarke, M.,Carter, J.,Meshinchi, S.,Mehlin, C.,Olson, J.M.,Strong, R.K.,Correnti, C.E. (deposition date: 2022-05-24, release date: 2023-06-07, Last modification date: 2023-12-20)

• Primary citation: Lin, I.,Rupert, P.B.,Pilat, K.,Ruff, R.O.,Friend, D.J.,Chan, M.K.,Clarke, M.,Hoffstrom, B.G.,Carter, J.,Meshinchi, S.,Bandaranayake, A.D.,Mehlin, C.,Olson, J.M.,Strong, R.K.,Correnti, C.E.; Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics; Front. Drug Discov., 3:-, 2023; DOI: 10.3389/fddsv.2023.1216516

Experimental method

X-RAY DIFFRACTION (2.6 Å)