8CZ8
Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
Summary for 8CZ8
Entry DOI | 10.2210/pdb8cz8/pdb |
Descriptor | scFv Anetumab, Mesothelin, cleaved form, scFv of A12 anti-mesothelin antibody, ... (5 entities in total) |
Functional Keywords | antibody, complex, tumor associated antigen, antitumor protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 137586.37 |
Authors | Bandaranayake, A.D.,Rupert, P.B.,Lin, I.,Pilat, K.,Ruff, R.O.,Friend, D.J.,Chan, M.K.,Clarke, M.,Carter, J.,Meshinchi, S.,Mehlin, C.,Olson, J.M.,Strong, R.K.,Correnti, C.E. (deposition date: 2022-05-24, release date: 2023-06-07, Last modification date: 2023-12-20) |
Primary citation | Lin, I.,Rupert, P.B.,Pilat, K.,Ruff, R.O.,Friend, D.J.,Chan, M.K.,Clarke, M.,Hoffstrom, B.G.,Carter, J.,Meshinchi, S.,Bandaranayake, A.D.,Mehlin, C.,Olson, J.M.,Strong, R.K.,Correnti, C.E. Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3:-, 2023 Cited by DOI: 10.3389/fddsv.2023.1216516PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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