8CZ8
Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (C, A) | scFv Anetumab | polymer | 247 | 25534.0 | 2 | Homo sapiens (Human) | ||
| 2 | B, C (M, E) | Mesothelin, cleaved form | polymer | 159 | 17676.0 | 2 | UniProt (Q13421) | Homo sapiens (human) | |
| 3 | D, F (D, B) | scFv of A12 anti-mesothelin antibody | polymer | 242 | 25294.9 | 2 | Homo sapiens (Human) | ||
| 4 | G, H, I, J, K... (C, D, A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | M, N, O, P, Q... (C, M, E, D, A...) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
M, E: 434 - 590 (UniProt: Q13421)
| PDB | External Database | Details |
|---|---|---|
| Gly 432 | - | expression tag |
| Ser 433 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 137010.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 576.4 | |
| All* | Total formula weight | 137586.4 |
