7LM8

Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with two cross-neutralizing antibodies CV38-142 and COVA1-16 Fabs isolated from COVID-19 patients

Summary for 7LM8

• Entry DOI: 10.2210/pdb7lm8/pdb
• Descriptor: Spike protein S1, COVA1-16 Fab heavy chain, COVA1-16 Fab light chain, ... (8 entities in total)
• Functional Keywords: sars-cov-2, sars-cov, antibody, spike, coronavirus, covid-19, sars, immune system, viral protein-immune system complex, cross-neutralization, synergy, viral protein, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 5
• Total formula weight: 124237.32

Authors

Liu, H.,Wilson, I.A. (deposition date: 2021-02-05, release date: 2021-03-31, Last modification date: 2023-10-18)

• Primary citation: Liu, H.,Yuan, M.,Huang, D.,Bangaru, S.,Zhao, F.,Lee, C.D.,Peng, L.,Barman, S.,Zhu, X.,Nemazee, D.,Burton, D.R.,van Gils, M.J.,Sanders, R.W.,Kornau, H.C.,Reincke, S.M.,Pruss, H.,Kreye, J.,Wu, N.C.,Ward, A.B.,Wilson, I.A.; A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection.; Cell Host Microbe, 29:806-818.e6, 2021; PubMed: 33894127; DOI: 10.1016/j.chom.2021.04.005

Experimental method

X-RAY DIFFRACTION (1.936 Å)