7LM8

Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with two cross-neutralizing antibodies CV38-142 and COVA1-16 Fabs isolated from COVID-19 patients

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Spike protein S1	polymer	231	26095.3	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
2	B (H)	COVA1-16 Fab heavy chain	polymer	232	25100.1	1		Homo sapiens (Human)
3	C (L)	COVA1-16 Fab light chain	polymer	215	23502.9	1		Homo sapiens (Human)
4	D (M)	CV38-142 Fab heavy chain	polymer	226	24068.0	1		Homo sapiens (Human)
5	E (N)	CV38-142 Fab light chain	polymer	217	23745.3	1		Homo sapiens (Human)
6	F (B)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G32152BH)
7	G, H, I, J, K... (A, H, L, M, N)	1,2-ETHANEDIOL	non-polymer		62.1	16	Chemie (EDO)
8	AA, W, X, Y, Z (N, A, H, L, M)	water	water		18.0	1007	Chemie (HOH)

Sequence modifications

A: 319 - 541 (UniProt: P0DTC2)

PDB	External Database	Details
Ser 542	-	expression tag
Gly 543	-	expression tag
His 544	-	expression tag
His 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	122511.6
Branched	Number of molecules	1
	Total formula weight	732.7
Non-Polymers*	Number of molecules	16
	Total formula weight	993.1
All*	Total formula weight	124237.3

*Water molecules are not included.