7V0P

Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a potently neutralizing human antibody IgG-106

Summary for 7V0P

Entry DOI	10.2210/pdb7v0p/pdb
EMDB information	26947
Descriptor	Spike glycoprotein E1, IgG 106 Fab heavy chain, IgG 106 Fab light chain, ... (4 entities in total)
Functional Keywords	cryo-em, single particle, virus neutralization, intra-virion crosslink, virus-immune system complex, virus/immune system
Biological source	Eastern equine encephalitis virus More
Total number of polymer chains	16
Total formula weight	477906.44
Authors	Bandyopadhyay, A.,Klose, T.,Kuhn, R.J. (deposition date: 2022-05-10, release date: 2023-04-05, Last modification date: 2024-02-21)
Primary citation	Williamson, L.E.,Bandyopadhyay, A.,Bailey, K.,Sirohi, D.,Klose, T.,Julander, J.G.,Kuhn, R.J.,Crowe Jr., J.E. Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 120:e2213690120-e2213690120, 2023 Cited by PubMed: 36961925 DOI: 10.1073/pnas.2213690120 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.2 Å)

Structure validation