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PDB: 10 results

8EBL
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BU of 8ebl by Molmil
Structure of KLHDC2 substrate binding domain bound to C-degron from EPHB2
Descriptor: GLU-ASP-SER-HIS-LYS-GLU-SER-ASN-ASP-CYS-SER-CYS-GLY-GLY, Kelch domain-containing protein 2
Authors:Scott, D.C, Schulman, B.A.
Deposit date:2022-08-31
Release date:2023-02-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol.Cell, 83, 2023
8SGF
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BU of 8sgf by Molmil
KLHDC2 Kelch Domain with KLHDC2 c-terminal peptide bound
Descriptor: GLYCEROL, HIS-SER-VAL-ASN-GLN-ARG-PHE-GLY-SER-ASN-ASN-THR-SER-GLY-SER, Kelch domain-containing protein 2
Authors:Digianantonio, K.M, Bekes, M, Langley, D.R, Zimmerman, K.
Deposit date:2023-04-12
Release date:2024-01-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.418 Å)
Cite:Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Nat.Struct.Mol.Biol., 31, 2024
8SGE
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BU of 8sge by Molmil
KLHDC2 Kelch Domain with ligand KDRLKZ-1
Descriptor: GLYCEROL, Kelch domain-containing protein 2, [(5P)-5-{3-[(2R)-butan-2-yl]-7-[(2-methoxyethoxy)carbonyl]-2-oxo-5,6,7,8-tetrahydro-1,7-naphthyridin-1(2H)-yl}-2-oxopyridin-1(2H)-yl]acetic acid
Authors:Digianantonio, K.M, Bekes, M, Langley, D.R, Zimmerman, K.
Deposit date:2023-04-12
Release date:2024-01-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.509 Å)
Cite:Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Nat.Struct.Mol.Biol., 31, 2024
8EBM
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BU of 8ebm by Molmil
Structure of KLHDC2 substrate binding domain bound to KLHDC2's C-degron mimic
Descriptor: ASN-GLN-ARG-PHE-GLY-SER-ASN-ASN-THR-SER-GLY-SER, Kelch domain-containing protein 2
Authors:Scott, D.C, Schulman, B.A.
Deposit date:2022-08-31
Release date:2023-02-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol.Cell, 83, 2023
8PIF
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BU of 8pif by Molmil
Fragment 12 in complex with KLHDC2
Descriptor: 1,2-ETHANEDIOL, 2-(furan-3-yl)ethanoic acid, Kelch domain-containing protein 2
Authors:Boettcher, J, Mayer, M.
Deposit date:2023-06-21
Release date:2023-07-12
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.782 Å)
Cite:KLHDC2 - The Next Level
To Be Published
6DO3
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BU of 6do3 by Molmil
KLHDC2 ubiquitin ligase in complex with SelK C-end degron
Descriptor: Kelch domain-containing protein 2, SelK C-end Degron
Authors:Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N.
Deposit date:2018-06-08
Release date:2018-12-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.165 Å)
Cite:Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase.
Mol. Cell, 72, 2018
6DO4
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BU of 6do4 by Molmil
KLHDC2 ubiquitin ligase in complex with SelS C-end degron
Descriptor: Kelch domain-containing protein 2, SELS C-END DEGRON
Authors:Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N.
Deposit date:2018-06-08
Release date:2018-12-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase.
Mol. Cell, 72, 2018
6DO5
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BU of 6do5 by Molmil
KLHDC2 ubiquitin ligase in complex with USP1 C-end degron
Descriptor: Kelch domain-containing protein 2, USP1 C-END DEGRON
Authors:Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N.
Deposit date:2018-06-08
Release date:2018-12-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase.
Mol. Cell, 72, 2018
8EBN
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BU of 8ebn by Molmil
Structure of KLHDC2-EloB/C tetrameric assembly
Descriptor: Elongin-B, Elongin-C, Kelch domain-containing protein 2
Authors:Scott, D.C, Schulman, B.A.
Deposit date:2022-08-31
Release date:2023-02-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol.Cell, 83, 2023
8SH2
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BU of 8sh2 by Molmil
KLHDC2 in complex with EloB and EloC
Descriptor: Elongin-B, Elongin-C, Kelch domain-containing protein 2
Authors:Digianantonio, K.M, Bekes, M.
Deposit date:2023-04-13
Release date:2024-01-03
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Nat.Struct.Mol.Biol., 31, 2024

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PDB entries from 2024-07-03

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