8EBL
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8SGF
| KLHDC2 Kelch Domain with KLHDC2 c-terminal peptide bound | Descriptor: | GLYCEROL, HIS-SER-VAL-ASN-GLN-ARG-PHE-GLY-SER-ASN-ASN-THR-SER-GLY-SER, Kelch domain-containing protein 2 | Authors: | Digianantonio, K.M, Bekes, M, Langley, D.R, Zimmerman, K. | Deposit date: | 2023-04-12 | Release date: | 2024-01-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.418 Å) | Cite: | Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat.Struct.Mol.Biol., 31, 2024
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8SGE
| KLHDC2 Kelch Domain with ligand KDRLKZ-1 | Descriptor: | GLYCEROL, Kelch domain-containing protein 2, [(5P)-5-{3-[(2R)-butan-2-yl]-7-[(2-methoxyethoxy)carbonyl]-2-oxo-5,6,7,8-tetrahydro-1,7-naphthyridin-1(2H)-yl}-2-oxopyridin-1(2H)-yl]acetic acid | Authors: | Digianantonio, K.M, Bekes, M, Langley, D.R, Zimmerman, K. | Deposit date: | 2023-04-12 | Release date: | 2024-01-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.509 Å) | Cite: | Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat.Struct.Mol.Biol., 31, 2024
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8EBM
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8PIF
| Fragment 12 in complex with KLHDC2 | Descriptor: | 1,2-ETHANEDIOL, 2-(furan-3-yl)ethanoic acid, Kelch domain-containing protein 2 | Authors: | Boettcher, J, Mayer, M. | Deposit date: | 2023-06-21 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.782 Å) | Cite: | KLHDC2 - The Next Level To Be Published
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8UXS
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6DO3
| KLHDC2 ubiquitin ligase in complex with SelK C-end degron | Descriptor: | Kelch domain-containing protein 2, SelK C-end Degron | Authors: | Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N. | Deposit date: | 2018-06-08 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.165 Å) | Cite: | Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase. Mol. Cell, 72, 2018
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6DO4
| KLHDC2 ubiquitin ligase in complex with SelS C-end degron | Descriptor: | Kelch domain-containing protein 2, SELS C-END DEGRON | Authors: | Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N. | Deposit date: | 2018-06-08 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase. Mol. Cell, 72, 2018
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6DO5
| KLHDC2 ubiquitin ligase in complex with USP1 C-end degron | Descriptor: | Kelch domain-containing protein 2, USP1 C-END DEGRON | Authors: | Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N. | Deposit date: | 2018-06-08 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase. Mol. Cell, 72, 2018
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8EBN
| Structure of KLHDC2-EloB/C tetrameric assembly | Descriptor: | Elongin-B, Elongin-C, Kelch domain-containing protein 2 | Authors: | Scott, D.C, Schulman, B.A. | Deposit date: | 2022-08-31 | Release date: | 2023-02-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. Mol.Cell, 83, 2023
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8SH2
| KLHDC2 in complex with EloB and EloC | Descriptor: | Elongin-B, Elongin-C, Kelch domain-containing protein 2 | Authors: | Digianantonio, K.M, Bekes, M. | Deposit date: | 2023-04-13 | Release date: | 2024-01-03 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat.Struct.Mol.Biol., 31, 2024
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