8SGF

KLHDC2 Kelch Domain with KLHDC2 c-terminal peptide bound

Summary for 8SGF

• Entry DOI: 10.2210/pdb8sgf/pdb
• Related: 8sge
• Descriptor: Kelch domain-containing protein 2, HIS-SER-VAL-ASN-GLN-ARG-PHE-GLY-SER-ASN-ASN-THR-SER-GLY-SER, GLYCEROL, ... (4 entities in total)
• Functional Keywords: klhdc2, peptide binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 86027.54

Authors

Digianantonio, K.M.,Bekes, M.,Langley, D.R.,Zimmerman, K. (deposition date: 2023-04-12, release date: 2024-01-03, Last modification date: 2024-02-28)

• Primary citation: Hickey, C.M.,Digianantonio, K.M.,Zimmermann, K.,Harbin, A.,Quinn, C.,Patel, A.,Gareiss, P.,Chapman, A.,Tiberi, B.,Dobrodziej, J.,Corradi, J.,Cacace, A.M.,Langley, D.R.,Bekes, M.; Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.; Nat.Struct.Mol.Biol., 31:311-322, 2024; PubMed: 38177675; DOI: 10.1038/s41594-023-01146-w

Experimental method

X-RAY DIFFRACTION (1.418 Å)