8SGF
KLHDC2 Kelch Domain with KLHDC2 c-terminal peptide bound
Summary for 8SGF
Entry DOI | 10.2210/pdb8sgf/pdb |
Related | 8sge |
Descriptor | Kelch domain-containing protein 2, HIS-SER-VAL-ASN-GLN-ARG-PHE-GLY-SER-ASN-ASN-THR-SER-GLY-SER, GLYCEROL, ... (4 entities in total) |
Functional Keywords | klhdc2, peptide binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 86027.54 |
Authors | Digianantonio, K.M.,Bekes, M.,Langley, D.R.,Zimmerman, K. (deposition date: 2023-04-12, release date: 2024-01-03, Last modification date: 2024-02-28) |
Primary citation | Hickey, C.M.,Digianantonio, K.M.,Zimmermann, K.,Harbin, A.,Quinn, C.,Patel, A.,Gareiss, P.,Chapman, A.,Tiberi, B.,Dobrodziej, J.,Corradi, J.,Cacace, A.M.,Langley, D.R.,Bekes, M. Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat.Struct.Mol.Biol., 31:311-322, 2024 Cited by PubMed: 38177675DOI: 10.1038/s41594-023-01146-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.418 Å) |
Structure validation
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