8SGE
KLHDC2 Kelch Domain with ligand KDRLKZ-1
Summary for 8SGE
Entry DOI | 10.2210/pdb8sge/pdb |
Descriptor | Kelch domain-containing protein 2, GLYCEROL, [(5P)-5-{3-[(2R)-butan-2-yl]-7-[(2-methoxyethoxy)carbonyl]-2-oxo-5,6,7,8-tetrahydro-1,7-naphthyridin-1(2H)-yl}-2-oxopyridin-1(2H)-yl]acetic acid, ... (4 entities in total) |
Functional Keywords | klhdc2, peptide binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 84127.67 |
Authors | Digianantonio, K.M.,Bekes, M.,Langley, D.R.,Zimmerman, K. (deposition date: 2023-04-12, release date: 2024-01-03, Last modification date: 2024-02-28) |
Primary citation | Hickey, C.M.,Digianantonio, K.M.,Zimmermann, K.,Harbin, A.,Quinn, C.,Patel, A.,Gareiss, P.,Chapman, A.,Tiberi, B.,Dobrodziej, J.,Corradi, J.,Cacace, A.M.,Langley, D.R.,Bekes, M. Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat.Struct.Mol.Biol., 31:311-322, 2024 Cited by PubMed: 38177675DOI: 10.1038/s41594-023-01146-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.509 Å) |
Structure validation
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