8SGE

KLHDC2 Kelch Domain with ligand KDRLKZ-1

Summary for 8SGE

• Entry DOI: 10.2210/pdb8sge/pdb
• Descriptor: Kelch domain-containing protein 2, GLYCEROL, [(5P)-5-{3-[(2R)-butan-2-yl]-7-[(2-methoxyethoxy)carbonyl]-2-oxo-5,6,7,8-tetrahydro-1,7-naphthyridin-1(2H)-yl}-2-oxopyridin-1(2H)-yl]acetic acid, ... (4 entities in total)
• Functional Keywords: klhdc2, peptide binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 84127.67

Authors

Digianantonio, K.M.,Bekes, M.,Langley, D.R.,Zimmerman, K. (deposition date: 2023-04-12, release date: 2024-01-03, Last modification date: 2024-02-28)

• Primary citation: Hickey, C.M.,Digianantonio, K.M.,Zimmermann, K.,Harbin, A.,Quinn, C.,Patel, A.,Gareiss, P.,Chapman, A.,Tiberi, B.,Dobrodziej, J.,Corradi, J.,Cacace, A.M.,Langley, D.R.,Bekes, M.; Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.; Nat.Struct.Mol.Biol., 31:311-322, 2024; PubMed: 38177675; DOI: 10.1038/s41594-023-01146-w

Experimental method

X-RAY DIFFRACTION (1.509 Å)