3OSN
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![BU of 3osn by Molmil](/molmil-images/mine/3osn) | |
3Q8P
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![BU of 3q8p by Molmil](/molmil-images/mine/3q8p) | Human DNA polymerase iota incorporating dCTP opposite 8-oxo-guanine | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | Authors: | Kirouac, K.N, Ling, H. | Deposit date: | 2011-01-06 | Release date: | 2011-02-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. Proc.Natl.Acad.Sci.USA, 108, 2011
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5ULX
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![BU of 5ulx by Molmil](/molmil-images/mine/5ulx) | |
3GV5
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![BU of 3gv5 by Molmil](/molmil-images/mine/3gv5) | |
3GV8
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![BU of 3gv8 by Molmil](/molmil-images/mine/3gv8) | |
3Q8Q
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![BU of 3q8q by Molmil](/molmil-images/mine/3q8q) | Human DNA polymerase iota incorporating dATP opposite 8-oxo-guanine | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | Authors: | Kirouac, K.N, Ling, H. | Deposit date: | 2011-01-06 | Release date: | 2011-02-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.031 Å) | Cite: | Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. Proc.Natl.Acad.Sci.USA, 108, 2011
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4FS2
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![BU of 4fs2 by Molmil](/molmil-images/mine/4fs2) | Base pairing mechanism of N2,3-ethenoguanine with dCTP by human polymerase iota | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*TP*(EFG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*(DOC))-3'), DNA polymerase iota, ... | Authors: | Zhao, L. | Deposit date: | 2012-06-26 | Release date: | 2012-08-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases. J.Biol.Chem., 287, 2012
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3G6X
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![BU of 3g6x by Molmil](/molmil-images/mine/3g6x) | |
3Q8S
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![BU of 3q8s by Molmil](/molmil-images/mine/3q8s) | |
3G6Y
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![BU of 3g6y by Molmil](/molmil-images/mine/3g6y) | |
4EBE
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![BU of 4ebe by Molmil](/molmil-images/mine/4ebe) | Conformationally Restrained North-methanocarba-2'-deoxyadenosine Corrects the Error-Prone Nature of Human DNA Polymerase Iota | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(P*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(P*CP*TP*GP*GP*GP*TP*CP*CP*T)-3', ... | Authors: | Eoff, R.L, Ketkar, A, Banerjee, S. | Deposit date: | 2012-03-23 | Release date: | 2012-06-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota. J.Am.Chem.Soc., 134, 2012
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3GV7
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![BU of 3gv7 by Molmil](/molmil-images/mine/3gv7) | |
3H4D
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![BU of 3h4d by Molmil](/molmil-images/mine/3h4d) | Ternary complex of human DNA polymerase iota with template U/T and incoming dGTP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC)), 5'-D(*TP*(BRU)P*GP*GP*GP*TP*CP*CP*T), ... | Authors: | Jain, R, Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2009-04-18 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Replication across template T/U by human DNA polymerase-iota. Structure, 17, 2009
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3G6V
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![BU of 3g6v by Molmil](/molmil-images/mine/3g6v) | |
1T3N
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![BU of 1t3n by Molmil](/molmil-images/mine/1t3n) | Structure of the catalytic core of DNA polymerase Iota in complex with DNA and dTTP | Descriptor: | MAGNESIUM ION, Primer DNA strand, THYMIDINE-5'-TRIPHOSPHATE, ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2004-04-27 | Release date: | 2004-07-20 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Nature, 430, 2004
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3H40
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![BU of 3h40 by Molmil](/molmil-images/mine/3h40) | Binary complex of human DNA polymerase iota with template U/T | Descriptor: | 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(BRU)P*GP*GP*GP*TP*CP*CP*T)-3', DNA polymerase iota, ... | Authors: | Jain, R, Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2009-04-17 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Replication across template T/U by human DNA polymerase-iota. Structure, 17, 2009
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1ZET
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![BU of 1zet by Molmil](/molmil-images/mine/1zet) | |
2DPJ
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![BU of 2dpj by Molmil](/molmil-images/mine/2dpj) | structure of hPoli with DNA and dTTP | Descriptor: | 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(EDA)P*GP*GP*GP*TP*CP*CP*T)-3', DNA polymerase iota, ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2006-05-12 | Release date: | 2006-07-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Hoogsteen base pair formation promotes synthesis opposite the 1,N(6)-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nat.Struct.Mol.Biol., 13, 2006
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2DPI
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![BU of 2dpi by Molmil](/molmil-images/mine/2dpi) | Ternary complex of hPoli with DNA and dCTP | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(EDA)P*GP*GP*GP*TP*CP*CP*T)-3', ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2006-05-12 | Release date: | 2006-07-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Hoogsteen base pair formation promotes synthesis opposite the 1,N(6)-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nat.Struct.Mol.Biol., 13, 2006
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2FLP
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![BU of 2flp by Molmil](/molmil-images/mine/2flp) | Binary complex of the catalytic core of human DNA polymerase iota with DNA (template G) | Descriptor: | DNA polymerase iota, DNA primer strand, DNA template strand | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2006-01-06 | Release date: | 2006-12-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Structure, 14, 2006
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3Q8R
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![BU of 3q8r by Molmil](/molmil-images/mine/3q8r) | Human DNA polymerase iota incorporating dGTP opposite 8-oxo-guanine | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | Authors: | Kirouac, K.N, Ling, H. | Deposit date: | 2011-01-06 | Release date: | 2011-02-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. Proc.Natl.Acad.Sci.USA, 108, 2011
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5KT2
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![BU of 5kt2 by Molmil](/molmil-images/mine/5kt2) | Teranry complex of human DNA polymerase iota(26-445) inserting dCMPNPP opposite template G in the presence of Mg2+ | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | Authors: | Choi, J.Y, Patra, A, Yeom, M, Lee, Y.S, Zhang, Q, Egli, M, Guengerich, F.P. | Deposit date: | 2016-07-11 | Release date: | 2016-08-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.488 Å) | Cite: | Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota. J.Biol.Chem., 291, 2016
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4FS1
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![BU of 4fs1 by Molmil](/molmil-images/mine/4fs1) | Base pairing mechanism of N2,3-ethenoguanine with dTTP by human polymerase iota | Descriptor: | DNA 5'-D(*TP*CP*TP*(EFG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*(DOC))-3', DNA polymerase iota, MAGNESIUM ION, ... | Authors: | Zhao, L. | Deposit date: | 2012-06-26 | Release date: | 2012-08-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases. J.Biol.Chem., 287, 2012
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3EPG
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![BU of 3epg by Molmil](/molmil-images/mine/3epg) | Structure of Human DNA Polymerase Iota complexed with N2-ethylguanine | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*DTP*DCP*DTP*(2EG)P*DGP*DGP*DGP*DTP*DCP*DCP*DTP*DAP*DGP*DGP*DAP*DCP*DCP*(DOC))-3', DNA polymerase iota, ... | Authors: | Pence, M.G. | Deposit date: | 2008-09-29 | Release date: | 2008-12-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Lesion bypass of N2-ethylguanine by human DNA polymerase iota. J.Biol.Chem., 284, 2009
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2ALZ
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![BU of 2alz by Molmil](/molmil-images/mine/2alz) | Ternary Complex of hPoli with DNA and dCTP | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*T)-3', ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2005-08-08 | Release date: | 2005-10-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Human DNA Polymerase iota Incorporates dCTP Opposite Template G via a G.C+ Hoogsteen Base Pair. Structure, 13, 2005
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