3OSN

Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase Iota

Summary for 3OSN

• Entry DOI: 10.2210/pdb3osn/pdb
• Related: 2ALZ 2FLL 3EPG 3EPI 3NGD
• Descriptor: 5'-D(*TP*CP*TP*(6OG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*(DOC))-3', DNA polymerase iota, THYMIDINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: hoogsteen base pair, protein-dna complex, y-family dna polymerase, translesion synthesis, nucleoside triphosphate, o6-methylguanine, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q9UNA4
• Total number of polymer chains: 3
• Total formula weight: 58594.27

Authors

Pence, M.G. (deposition date: 2010-09-09, release date: 2010-10-20, Last modification date: 2023-09-06)

• Primary citation: Pence, M.G.,Choi, J.Y.,Egli, M.,Guengerich, F.P.; Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase {iota}.; J.Biol.Chem., 285:40666-40672, 2010; PubMed: 20961860; DOI: 10.1074/jbc.M110.183665

Experimental method

X-RAY DIFFRACTION (1.9 Å)