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PDB: 25 results

5EP6
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BU of 5ep6 by Molmil
The crystal structure of NAP1 in complex with TBK1
Descriptor: 5-azacytidine-induced protein 2, GLYCEROL, Serine/threonine-protein kinase TBK1
Authors:Li, F, Xie, X, Liu, J, Pan, L.
Deposit date:2015-11-11
Release date:2016-09-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.451 Å)
Cite:Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.
Nat Commun, 7, 2016
4EFO
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Crystal structure of the ubiquitin-like domain of human TBK1
Descriptor: Serine/threonine-protein kinase TBK1
Authors:Li, J, Li, J, Miyahira, A, Sun, J, Liu, Y, Cheng, G, Liang, H.
Deposit date:2012-03-30
Release date:2012-06-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:Crystal structure of the ubiquitin-like domain of human TBK1.
Protein Cell, 3, 2012
4EUU
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BU of 4euu by Molmil
Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172
Descriptor: GLYCEROL, IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, ...
Authors:Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C.
Deposit date:2012-04-25
Release date:2012-05-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
5EOF
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BU of 5eof by Molmil
Crystal structure of OPTN NTD and TBK1 CTD complex
Descriptor: Optineurin, Serine/threonine-protein kinase TBK1
Authors:Li, F, Xie, X, Liu, J, Pan, L.
Deposit date:2015-11-10
Release date:2016-09-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.
Nat Commun, 7, 2016
4IM0
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BU of 4im0 by Molmil
Structure of Tank-Binding Kinase 1
Descriptor: N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, Serine/threonine-protein kinase TBK1
Authors:Tu, D, Eck, M.J.
Deposit date:2013-01-01
Release date:2013-03-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4001 Å)
Cite:Structure and ubiquitination-dependent activation of TANK-binding kinase 1.
Cell Rep, 3, 2013
4IM2
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BU of 4im2 by Molmil
Structure of Tank-Binding Kinase 1
Descriptor: CHLORIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1
Authors:Tu, D, Eck, M.J.
Deposit date:2013-01-01
Release date:2013-03-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5001 Å)
Cite:Structure and ubiquitination-dependent activation of TANK-binding kinase 1.
Cell Rep, 3, 2013
5EOA
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BU of 5eoa by Molmil
Crystal structure of OPTN E50K mutant and TBK1 complex
Descriptor: Optineurin, Serine/threonine-protein kinase TBK1
Authors:Li, F, Xie, X, Liu, J, Pan, L.
Deposit date:2015-11-10
Release date:2016-09-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.
Nat Commun, 7, 2016
4EUT
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BU of 4eut by Molmil
Structure of BX-795 Complexed with Unphosphorylated Human TBK1 Kinase-ULD Domain
Descriptor: IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, SULFATE ION, ...
Authors:Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C.
Deposit date:2012-04-25
Release date:2012-05-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
4IWO
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BU of 4iwo by Molmil
Crystal structure and mechanism of activation of TBK1
Descriptor: N-{3-[(5-cyclopropyl-2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, Serine/threonine-protein kinase TBK1
Authors:Panne, D, Larabi, A.
Deposit date:2013-01-24
Release date:2013-03-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal structure and mechanism of activation of TANK-binding kinase 1.
Cell Rep, 3, 2013
6RSU
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BU of 6rsu by Molmil
TBK1 in complex with Inhibitor compound 35
Descriptor: 3,3,3-tris(fluoranyl)-1-[4-[(1~{R})-1-[2-[[(2~{S})-5-(5-propan-2-yloxypyrimidin-4-yl)-2,3-dihydro-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one, Serine/threonine-protein kinase TBK1
Authors:Panne, D, Hillig, R.C, Rengachari, S.
Deposit date:2019-05-22
Release date:2020-04-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor.
J.Med.Chem., 63, 2020
4IWQ
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BU of 4iwq by Molmil
Crystal structure and mechanism of activation of TBK1
Descriptor: N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, Serine/threonine-protein kinase TBK1
Authors:Panne, D, Larabi, A.
Deposit date:2013-01-24
Release date:2013-03-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure and mechanism of activation of TANK-binding kinase 1.
Cell Rep, 3, 2013
4IWP
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BU of 4iwp by Molmil
Crystal structure and mechanism of activation of TBK1
Descriptor: N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1
Authors:Panne, D, Larabi, A.
Deposit date:2013-01-24
Release date:2013-03-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.065 Å)
Cite:Crystal structure and mechanism of activation of TANK-binding kinase 1.
Cell Rep, 3, 2013
6RSR
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BU of 6rsr by Molmil
TBK1 in complex with compound 2
Descriptor: Serine/threonine-protein kinase TBK1, ~{N}-(cyclopropen-1-ylmethyl)-2-[[4-[[4-[3,3,3-tris(fluoranyl)propanoyl]piperazin-1-yl]methyl]pyridin-2-yl]amino]-1~{H}-benzimidazole-5-carboxamide
Authors:Panne, D, Hillig, R.C, Rengachari, S.
Deposit date:2019-05-22
Release date:2020-01-01
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor.
J.Med.Chem., 63, 2020
6CQ0
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BU of 6cq0 by Molmil
TBK1 in Complex with Dimethyl Amino Analog of Amlexanox
Descriptor: 2-amino-7-[3-(dimethylamino)propyl]-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2018-03-14
Release date:2018-12-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.
Bioorg. Med. Chem., 26, 2018
6BOD
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BU of 6bod by Molmil
TBK1 in complex with ethyl ester analog of amlexanox
Descriptor: Serine/threonine-protein kinase TBK1, ethyl 2-amino-5-oxo-7-(propan-2-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylate
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2017-11-19
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.197 Å)
Cite:Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
6CQ4
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BU of 6cq4 by Molmil
TBK1 in Complex with Cyclohexyl Analog of Amlexanox
Descriptor: 2-amino-7-(4,4-difluorocyclohexyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2018-03-14
Release date:2018-12-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.
Bioorg. Med. Chem., 26, 2018
6RST
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BU of 6rst by Molmil
TBK1 in complex with inhibitor compound 24
Descriptor: 1-[4-[(1~{R})-1-[2-[[5-[1-(cyclopropylmethyl)pyrazol-4-yl]-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]-3,3,3-tris(fluoranyl)propan-1-one, Serine/threonine-protein kinase TBK1
Authors:Panne, D, Hillig, R.C, Rengachari, S.
Deposit date:2019-05-22
Release date:2020-01-01
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor.
J.Med.Chem., 63, 2020
6NT9
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BU of 6nt9 by Molmil
Cryo-EM structure of the complex between human TBK1 and chicken STING
Descriptor: Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein
Authors:Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of STING binding with and phosphorylation by TBK1.
Nature, 567, 2019
6BNY
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BU of 6bny by Molmil
TBK1 in complex with tetrazole analog of amlexanox
Descriptor: 2-amino-7-(propan-2-yl)-3-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridin-5-one, Serine/threonine-protein kinase TBK1
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2017-11-17
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.341 Å)
Cite:Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
4IM3
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BU of 4im3 by Molmil
Structure of Tank-Binding Kinase 1
Descriptor: CHLORIDE ION, MERCURY (II) ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, ...
Authors:Tu, D, Eck, M.J.
Deposit date:2013-01-01
Release date:2013-03-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.342 Å)
Cite:Structure and ubiquitination-dependent activation of TANK-binding kinase 1.
Cell Rep, 3, 2013
6CQ5
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BU of 6cq5 by Molmil
TBK1 in Complex with Sulfone Analog of Amlexanox
Descriptor: 2-amino-7-(1,1-dioxo-1lambda~6~-thian-4-yl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2018-03-14
Release date:2018-12-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.354 Å)
Cite:Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.
Bioorg. Med. Chem., 26, 2018
6O8B
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BU of 6o8b by Molmil
Crystal structure of STING CTD in complex with TBK1
Descriptor: N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein
Authors:Li, P, Zhao, B, Du, F.
Deposit date:2019-03-09
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
6BOE
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BU of 6boe by Molmil
TBK1 in complex with amide-coupled tetrazole analog of amlexanox
Descriptor: 2-amino-5-oxo-7-(propan-2-yl)-N-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide, Serine/threonine-protein kinase TBK1
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2017-11-19
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
5W5V
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BU of 5w5v by Molmil
TBK1 co-crystal structure with amlexanox
Descriptor: 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2017-06-15
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.645 Å)
Cite:Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
4IW0
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BU of 4iw0 by Molmil
Crystal structure and mechanism of activation of TBK1
Descriptor: N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1
Authors:Larabi, A, Devos, J.M, Ng, S.-L, Nanao, M.H, Round, A, Maniatis, T, Panne, D.
Deposit date:2013-01-23
Release date:2013-03-13
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal structure and mechanism of activation of TANK-binding kinase 1.
Cell Rep, 3, 2013

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