4EUU
Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172
Summary for 4EUU
Entry DOI | 10.2210/pdb4euu/pdb |
Related | 4EUT |
Descriptor | Serine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, IODIDE ION, ... (6 entities in total) |
Functional Keywords | kinase, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q9UHD2 |
Total number of polymer chains | 2 |
Total formula weight | 74727.57 |
Authors | Ma, X.,Helgason, E.,Phung, Q.T.,Quan, C.L.,Iyer, R.S.,Lee, M.W.,Bowman, K.K.,Starovasnik, M.A.,Dueber, E.C. (deposition date: 2012-04-25, release date: 2012-05-23, Last modification date: 2017-11-15) |
Primary citation | Ma, X.,Helgason, E.,Phung, Q.T.,Quan, C.L.,Iyer, R.S.,Lee, M.W.,Bowman, K.K.,Starovasnik, M.A.,Dueber, E.C. Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation. Proc.Natl.Acad.Sci.USA, 109:9378-9383, 2012 Cited by PubMed: 22619329DOI: 10.1073/pnas.1121552109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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