6BOD

TBK1 in complex with ethyl ester analog of amlexanox

Summary for 6BOD

Entry DOI	10.2210/pdb6bod/pdb
Descriptor	Serine/threonine-protein kinase TBK1, ethyl 2-amino-5-oxo-7-(propan-2-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylate (2 entities in total)
Functional Keywords	tbk1, kinase, amlexanox, obesity, diabetes, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	76352.27
Authors	Beyett, T.S.,Tesmer, J.J.G. (deposition date: 2017-11-19, release date: 2018-09-26, Last modification date: 2023-10-04)
Primary citation	Beyett, T.S.,Gan, X.,Reilly, S.M.,Chang, L.,Gomez, A.V.,Saltiel, A.R.,Showalter, H.D.,Tesmer, J.J.G. Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition. Mol. Pharmacol., 94:1210-1219, 2018 Cited by PubMed: 30082428 DOI: 10.1124/mol.118.112185 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.197 Å)

Structure validation