6BNY
TBK1 in complex with tetrazole analog of amlexanox
Summary for 6BNY
Entry DOI | 10.2210/pdb6bny/pdb |
Descriptor | Serine/threonine-protein kinase TBK1, 2-amino-7-(propan-2-yl)-3-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridin-5-one (2 entities in total) |
Functional Keywords | tbk1, kinase, amlexanox, obesity, diabetes, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 76348.24 |
Authors | Beyett, T.S.,Tesmer, J.J.G. (deposition date: 2017-11-17, release date: 2018-09-26, Last modification date: 2023-10-04) |
Primary citation | Beyett, T.S.,Gan, X.,Reilly, S.M.,Chang, L.,Gomez, A.V.,Saltiel, A.R.,Showalter, H.D.,Tesmer, J.J.G. Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition. Mol. Pharmacol., 94:1210-1219, 2018 Cited by PubMed: 30082428DOI: 10.1124/mol.118.112185 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.341 Å) |
Structure validation
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