5EOA

Crystal structure of OPTN E50K mutant and TBK1 complex

Summary for 5EOA

• Entry DOI: 10.2210/pdb5eoa/pdb
• Related: 5EOF
• Descriptor: Optineurin, Serine/threonine-protein kinase TBK1 (3 entities in total)
• Functional Keywords: optineurin, tbk1, poag, als, protein binding-transferase complex, protein binding/transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm, perinuclear region: Q96CV9; Cytoplasm : Q9UHD2
• Total number of polymer chains: 4
• Total formula weight: 31796.23

Authors

Li, F.,Xie, X.,Liu, J.,Pan, L. (deposition date: 2015-11-10, release date: 2016-09-28, Last modification date: 2024-03-20)

• Primary citation: Li, F.,Xie, X.,Wang, Y.,Liu, J.,Cheng, X.,Guo, Y.,Gong, Y.,Hu, S.,Pan, L.; Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.; Nat Commun, 7:12708-12708, 2016; PubMed: 27620379; DOI: 10.1038/ncomms12708

Experimental method

X-RAY DIFFRACTION (2.503 Å)