4IM0

Structure of Tank-Binding Kinase 1

Summary for 4IM0

• Entry DOI: 10.2210/pdb4im0/pdb
• Related: 4IM2 4IM3
• Descriptor: Serine/threonine-protein kinase TBK1, N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide (3 entities in total)
• Functional Keywords: kinase, serine/threonine kinase, mrt67307, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 76649.67

Authors

Tu, D.,Eck, M.J. (deposition date: 2013-01-01, release date: 2013-03-06, Last modification date: 2024-02-28)

• Primary citation: Tu, D.,Zhu, Z.,Zhou, A.Y.,Yun, C.H.,Lee, K.E.,Toms, A.V.,Li, Y.,Dunn, G.P.,Chan, E.,Thai, T.,Yang, S.,Ficarro, S.B.,Marto, J.A.,Jeon, H.,Hahn, W.C.,Barbie, D.A.,Eck, M.J.; Structure and ubiquitination-dependent activation of TANK-binding kinase 1.; Cell Rep, 3:747-758, 2013; PubMed: 23453972; DOI: 10.1016/j.celrep.2013.01.033

Experimental method

X-RAY DIFFRACTION (2.4001 Å)