4IWQ
Crystal structure and mechanism of activation of TBK1
Summary for 4IWQ
| Entry DOI | 10.2210/pdb4iwq/pdb |
| Related | 4IW0 4IWO 4IWP |
| Descriptor | Serine/threonine-protein kinase TBK1, N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide (2 entities in total) |
| Functional Keywords | kinase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: Q9UHD2 |
| Total number of polymer chains | 1 |
| Total formula weight | 76330.40 |
| Authors | Panne, D.,Larabi, A. (deposition date: 2013-01-24, release date: 2013-03-13, Last modification date: 2024-02-28) |
| Primary citation | Larabi, A.,Devos, J.M.,Ng, S.L.,Nanao, M.H.,Round, A.,Maniatis, T.,Panne, D. Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep, 3:734-746, 2013 Cited by PubMed: 23453971DOI: 10.1016/j.celrep.2013.01.034 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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