Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 20 results
6GEI
DownloadVisualize
BU of 6gei by Molmil
TEAD4 (216-434);E263A+Y429F COMPLEXED WITH YAP PEPTIDE (60- 100);S94A AND MYRISTOATE (COVALENTLY BOUND TO LYS344, NOT CYS367!) AT 1.65A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA
Descriptor: MYRISTIC ACID, PHOSPHATE ION, Transcriptional coactivator YAP1, ...
Authors:Kallen, J.
Deposit date:2018-04-26
Release date:2018-09-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.
Protein Sci., 27, 2018
6HIK
DownloadVisualize
BU of 6hik by Molmil
X-ray structure of TEAD4(Y429H) mutant) complexed with YAP (wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
Descriptor: MYRISTIC ACID, PHOSPHATE ION, Transcriptional coactivator YAP1, ...
Authors:Kallen, J.
Deposit date:2018-08-30
Release date:2019-04-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy.
Febs J., 286, 2019
6SEN
DownloadVisualize
BU of 6sen by Molmil
TEAD4 bound to a FAM181A peptide
Descriptor: Protein FAM181A, SULFATE ION, Transcriptional enhancer factor TEF-3
Authors:Scheufler, C, Villard, F.
Deposit date:2019-07-30
Release date:2019-11-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors.
Protein Sci., 29, 2020
8A8R
DownloadVisualize
BU of 8a8r by Molmil
Crystal structure of TEAD4 in complex with YAP peptide
Descriptor: Isoform 7 of Transcriptional coactivator YAP1, MYRISTIC ACID, Transcriptional enhancer factor TEF-3
Authors:Scheufler, C, Kallen, J.
Deposit date:2022-06-23
Release date:2022-12-28
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.696 Å)
Cite:N-terminal beta-strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor.
Protein Sci., 32, 2023
6GEC
DownloadVisualize
BU of 6gec by Molmil
TEAD4 (216-434) COMPLEXED WITH YAP PEPTIDE (60-100);S94A AND MYRISTOATE (COVALENTLY BOUND) AT 1.70A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA
Descriptor: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3
Authors:Kallen, J.
Deposit date:2018-04-26
Release date:2018-09-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.
Protein Sci., 27, 2018
6GE6
DownloadVisualize
BU of 6ge6 by Molmil
X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface
Descriptor: MYRISTIC ACID, PHOSPHATE ION, Transcriptional coactivator YAP1, ...
Authors:Kallen, J.
Deposit date:2018-04-25
Release date:2018-09-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.
Protein Sci., 27, 2018
6GE3
DownloadVisualize
BU of 6ge3 by Molmil
X-ray structure of TEAD4 (wildtype) complexed with YAP (wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface
Descriptor: GLYCEROL, MYRISTIC ACID, Transcriptional coactivator YAP1, ...
Authors:Kallen, J.
Deposit date:2018-04-25
Release date:2018-09-19
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.
Protein Sci., 27, 2018
5OAQ
DownloadVisualize
BU of 5oaq by Molmil
TEAD4 COMPLEXED WITH YAP PEPTIDE AND MYRISTATE (COVALENTLY BOUND)
Descriptor: GLYCEROL, MYRISTIC ACID, Transcriptional coactivator YAP1, ...
Authors:Kallen, J.
Deposit date:2017-06-23
Release date:2017-10-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Effect of the acylation of TEAD4 on its interaction with co-activators YAP and TAZ.
Protein Sci., 26, 2017
6GEE
DownloadVisualize
BU of 6gee by Molmil
TEAD4 (216-434);E263A COMPLEXED WITH YAP PEPTIDE (60-100); S94A AND MYRISTOATE (COVALENTLY BOUND) AT 1.96A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA
Descriptor: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3
Authors:Kallen, J.
Deposit date:2018-04-26
Release date:2018-09-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.
Protein Sci., 27, 2018
6GE4
DownloadVisualize
BU of 6ge4 by Molmil
TEAD4 (216-434);E263A COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 1.97A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA
Descriptor: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3
Authors:Kallen, J.
Deposit date:2018-04-25
Release date:2018-09-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.
Protein Sci., 27, 2018
8CAA
DownloadVisualize
BU of 8caa by Molmil
Crystal structure of TEAD4 in complex with YTP-13
Descriptor: (2~{R})-2-[2-chloranyl-5-[2-chloranyl-4-(trifluoromethyl)phenoxy]phenyl]sulfanylpropanoic acid, 4-[bis(fluoranyl)methoxy]-2-[(2~{S})-5-chloranyl-6-fluoranyl-2-[[(4-oxidanylcyclohexyl)amino]methyl]-2-phenyl-3~{H}-1-benzofuran-4-yl]-3-fluoranyl-benzamide, PHOSPHATE ION, ...
Authors:Scheufler, C, Kallen, J.
Deposit date:2023-01-24
Release date:2023-04-12
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.
Chemmedchem, 18, 2023
6Q36
DownloadVisualize
BU of 6q36 by Molmil
TEAD4(216-434) complexed with optimized peptide 9 and myristoate (covalently bound) at 2.01A resolution: Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence
Descriptor: ACE-PRO-6CW-ARG-LEU-ARG-LYS-2JH-HYP-ASP-SER-PHE-ALN-LYS-GLU-PRO-NH2, MYRISTIC ACID, PHOSPHATE ION, ...
Authors:Kallen, J.
Deposit date:2018-12-03
Release date:2019-07-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence.
Bioorg.Med.Chem.Lett., 29, 2019
6GE5
DownloadVisualize
BU of 6ge5 by Molmil
TEAD4 (216-434);Y429F COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 2.05A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA
Descriptor: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3
Authors:Kallen, J.
Deposit date:2018-04-25
Release date:2018-09-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.
Protein Sci., 27, 2018
6Q2X
DownloadVisualize
BU of 6q2x by Molmil
TEAD4 (216-434) COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 2.1A (P41212 CRYSTAL FORM)
Descriptor: GLYCEROL, MYRISTIC ACID, Transcriptional coactivator YAP1, ...
Authors:Kallen, J.
Deposit date:2018-12-03
Release date:2019-07-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence.
Bioorg.Med.Chem.Lett., 29, 2019
6GEG
DownloadVisualize
BU of 6geg by Molmil
TEAD4 (216-434);Y429F COMPLEXED WITH YAP PEPTIDE (60-100); S94A AND MYRISTOATE (COVALENTLY BOUND) AT 2.23A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA
Descriptor: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3
Authors:Kallen, J.
Deposit date:2018-04-26
Release date:2018-09-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.
Protein Sci., 27, 2018
8C17
DownloadVisualize
BU of 8c17 by Molmil
Crystal structure of TEAD4 in complex with peptide 1
Descriptor: GLYCEROL, MYRISTIC ACID, Stapled peptide, ...
Authors:Scheufler, C, Kallen, J.
Deposit date:2022-12-20
Release date:2023-03-15
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Biochemical and Structural Characterization of a Peptidic Inhibitor of the YAP:TEAD Interaction That Binds to the alpha-Helix Pocket on TEAD.
Acs Chem.Biol., 18, 2023
6GEK
DownloadVisualize
BU of 6gek by Molmil
TEAD4 (216-434);Y429F COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 2.28A (P212121 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA
Descriptor: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3
Authors:Kallen, J.
Deposit date:2018-04-26
Release date:2018-09-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.
Protein Sci., 27, 2018
6SEO
DownloadVisualize
BU of 6seo by Molmil
TEAD4 bound to a FAM181B peptide
Descriptor: Protein FAM181B, Transcriptional enhancer factor TEF-3
Authors:Scheufler, C, Villard, F.
Deposit date:2019-07-30
Release date:2019-11-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors.
Protein Sci., 29, 2020
5GZB
DownloadVisualize
BU of 5gzb by Molmil
Crystal Structure of Transcription Factor TEAD4 in Complex with M-CAT DNA
Descriptor: DNA (5'-D(*GP*AP*GP*AP*GP*GP*AP*AP*TP*GP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*CP*AP*TP*TP*CP*CP*TP*CP*TP*C)-3'), GLYCEROL, ...
Authors:He, F, Shi, Z.B, Zhou, Z.C.
Deposit date:2016-09-28
Release date:2017-04-19
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:DNA-binding mechanism of the Hippo pathway transcription factor TEAD4
Oncogene, 36, 2017
5NO6
DownloadVisualize
BU of 5no6 by Molmil
TEAD4-HOXB13 complex bound to DNA
Descriptor: DNA, Homeobox protein Hox-B13, Transcriptional enhancer factor TEF-3
Authors:Morgunova, E, Jolma, A, Yin, Y, Popov, A, Taipale, J.
Deposit date:2017-04-11
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:TEAD4-HOXB13 complex bound to DNA
To Be Published

223532

PDB entries from 2024-08-07

PDB statisticsPDBj update infoContact PDBjnumon