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PDB: 30 results

1W96
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Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces cerevisiae in Complex with Soraphen A
Descriptor: ACETYL-COENZYME A CARBOXYLASE, SORAPHEN A
Authors:Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L.
Deposit date:2004-10-06
Release date:2005-01-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
4WZ8
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Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 6
Descriptor: 1'-(2H-indazol-5-ylcarbonyl)-1-(propan-2-yl)-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-one, Acetyl-CoA carboxylase
Authors:Vajdos, F.F.
Deposit date:2014-11-18
Release date:2014-12-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes.
J.Med.Chem., 57, 2014
3K8X
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Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with tepraloxydim
Descriptor: (5S)-2-[(1E)-N-{[(2E)-3-chloroprop-2-en-1-yl]oxy}propanimidoyl]-3-hydroxy-5-(tetrahydro-2H-pyran-4-yl)cyclohex-2-en-1-one, Acetyl-CoA carboxylase
Authors:Xiang, S, Callaghan, M.M, Watson, K.G, Tong, L.
Deposit date:2009-10-15
Release date:2009-12-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim.
Proc.Natl.Acad.Sci.USA, 106, 2009
5CTE
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BU of 5cte by Molmil
Humanized yeast ACC carboxyltransferase domain bound to 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate
Descriptor: 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate, Acetyl-CoA carboxylase, SULFATE ION
Authors:Vajdos, F.F.
Deposit date:2015-07-23
Release date:2015-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg.Med.Chem.Lett., 25, 2015
5CTB
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BU of 5ctb by Molmil
Humanized yeast ACC carboxyltransferase domain bound to 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Descriptor: 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one, Acetyl-CoA carboxylase, SULFATE ION
Authors:Vajdos, F.F.
Deposit date:2015-07-23
Release date:2015-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg.Med.Chem.Lett., 25, 2015
3TVU
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BU of 3tvu by Molmil
Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 3
Descriptor: 4-({4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl}carbonyl)-2-phenylquinoline, Acetyl-CoA carboxylase
Authors:Rajamohan, F, Marr, E, Reyes, A, Landro, J.A, Anderson, M.D, Corbett, J.W, Dirico, K.J, Harwood, J.H, Tu, M, Vajdos, F.F.
Deposit date:2011-09-20
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion.
J.Biol.Chem., 286, 2011
3H0S
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BU of 3h0s by Molmil
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 7
Descriptor: 1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one, Acetyl-CoA carboxylase, SULFATE ION
Authors:Vajdos, F.
Deposit date:2009-04-10
Release date:2010-04-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Bioorg.Med.Chem.Lett., 20, 2010
3H0Q
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BU of 3h0q by Molmil
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 3
Descriptor: 4-({4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl}carbonyl)-2-phenylquinoline, Acetyl-CoA carboxylase
Authors:Zhang, H, Tong, L.
Deposit date:2009-04-10
Release date:2010-04-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Bioorg.Med.Chem.Lett., 20, 2010
1UYR
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BU of 1uyr by Molmil
Acetyl-CoA Carboxylase Carboxyltransferase Domain in complex with inhibitor Diclofop
Descriptor: 2-[4-(2,4-DICHLOROPHENOXY)PHENOXY]PROPANOIC ACID, ACETYL-COA CARBOXYLASE
Authors:Zhang, H, Tweel, B, Tong, L.
Deposit date:2004-03-02
Release date:2004-03-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop
Proc.Natl.Acad.Sci.USA, 101, 2004
5CS0
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BU of 5cs0 by Molmil
Crystal structure of domains AC1-AC2 of yeast acetyl-CoA carboxylase
Descriptor: Acetyl-CoA carboxylase
Authors:Wei, J, Tong, L.
Deposit date:2015-07-23
Release date:2015-10-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
Nature, 526, 2015
1UYT
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BU of 1uyt by Molmil
Acetyl-CoA carboxylase carboxyltransferase domain
Descriptor: ACETYL-COA CARBOXYLASE
Authors:Zhang, H, Tweel, B, Tong, L.
Deposit date:2004-03-02
Release date:2004-03-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop.
Proc.Natl.Acad.Sci.USA, 101, 2004
1W93
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BU of 1w93 by Molmil
Crystal Structure of Biotin Carboxylase Domain of Acetyl-Coenzyme A Carboxylase from Saccharomyces cerevisiae
Descriptor: ACETYL-COENZYME A CARBOXYLASE
Authors:Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L.
Deposit date:2004-10-05
Release date:2005-01-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
1UYV
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BU of 1uyv by Molmil
Acetyl-CoA carboxylase carboxyltransferase domain L1705I/V1967I mutant
Descriptor: ACETYL-COA CARBOXYLASE
Authors:Zhang, H, Tweel, B, Tong, L.
Deposit date:2004-03-02
Release date:2004-03-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop
Proc.Natl.Acad.Sci.USA, 101, 2004
5CTC
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BU of 5ctc by Molmil
Humanized yeast ACC carboxyltransferase domain bound to tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate
Descriptor: Acetyl-CoA carboxylase, SULFATE ION, tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate
Authors:Vajdos, F.F.
Deposit date:2015-07-23
Release date:2015-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg.Med.Chem.Lett., 25, 2015
3TZ3
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BU of 3tz3 by Molmil
Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 2
Descriptor: 6-{[1-(anthracen-9-ylcarbonyl)piperidin-4-yl]methyl}-2-methylquinoline, Acetyl-CoA carboxylase
Authors:Rajamohan, F, Marr, E, Reyes, A, Landro, J.A, Anderson, M.D, Corbett, J.W, Dirico, K.J, Harwood, J.H, Tu, M, Vajdos, F.F.
Deposit date:2011-09-26
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion.
J.Biol.Chem., 286, 2011
1OD4
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BU of 1od4 by Molmil
Acetyl-CoA Carboxylase Carboxyltransferase Domain
Descriptor: ACETYL-COENZYME A CARBOXYLASE, ADENINE
Authors:Zhang, H, Yang, Z, Shen, Y, Tong, L.
Deposit date:2003-02-12
Release date:2003-04-03
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase.
Science, 299, 2003
1OD2
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BU of 1od2 by Molmil
Acetyl-CoA Carboxylase Carboxyltransferase Domain
Descriptor: ACETYL COENZYME *A, ACETYL-COENZYME A CARBOXYLASE, ADENINE
Authors:Zhang, H, Yang, Z, Shen, Y, Tong, L.
Deposit date:2003-02-12
Release date:2003-04-03
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase.
Science, 299, 2003
3TV5
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Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 1
Descriptor: (3R)-1'-(9-ANTHRYLCARBONYL)-3-(MORPHOLIN-4-YLCARBONYL)-1,4'-BIPIPERIDINE, Acetyl-CoA carboxylase
Authors:Rajamohan, F, Marr, E, Reyes, A, Landro, J.A, Anderson, M.D, Corbett, J.W, Dirico, K.J, Harwood, J.H, Tu, M, Vajdos, F.F.
Deposit date:2011-09-19
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion.
J.Biol.Chem., 286, 2011
3TVW
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BU of 3tvw by Molmil
Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 4
Descriptor: Acetyl-CoA carboxylase, [4-(2H-chromen-3-ylmethyl)piperazin-1-yl]-[3-(1H-pyrazol-5-yl)phenyl]methanone
Authors:Rajamohan, F, Marr, E, Reyes, A, Landro, J.A, Anderson, M.D, Corbett, J.W, Dirico, K.J, Harwood, J.H, Tu, M, Vajdos, F.F.
Deposit date:2011-09-20
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion.
J.Biol.Chem., 286, 2011
1UYS
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BU of 1uys by Molmil
Acetyl-CoA carboxylase carboxyltransferase domain in complex with inhibitor haloxyfop
Descriptor: (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid, ACETYL-COA CARBOXYLASE
Authors:Zhang, H, Tweel, B, Tong, L.
Deposit date:2004-03-02
Release date:2004-03-29
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop
Proc.Natl.Acad.Sci.USA, 101, 2004
3H0J
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BU of 3h0j by Molmil
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 2
Descriptor: 6-{[1-(anthracen-9-ylcarbonyl)piperidin-4-yl]methyl}-2-methylquinoline, Acetyl-CoA carboxylase
Authors:Zhang, H, Tong, L.
Deposit date:2009-04-09
Release date:2010-04-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Bioorg.Med.Chem.Lett., 20, 2010
3PGQ
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BU of 3pgq by Molmil
Crystal Structure of the Carboxyltransferase Domain of S. cerevisiae Acetyl CoA Carboxylase in Complex with Pinoxaden
Descriptor: 8-(2-ethenyl-6-ethyl-4-methylphenyl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione, Acetyl-CoA carboxylase
Authors:Tong, L, Yu, L.P.C, Kim, Y.S.
Deposit date:2010-11-02
Release date:2010-12-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden.
Proc.Natl.Acad.Sci.USA, 107, 2010
1W2X
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BU of 1w2x by Molmil
Crystal structure of the carboxyltransferase domain of acetyl- coenzyme A carboxylase in complex with CP-640186
Descriptor: (3R)-1'-(9-ANTHRYLCARBONYL)-3-(MORPHOLIN-4-YLCARBONYL)-1,4'-BIPIPERIDINE, ACETYL-COA CARBOXYLASE
Authors:Zhang, H, Tweel, B, Li, J, Tong, L.
Deposit date:2004-07-09
Release date:2004-09-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Carboxyltransferase Domain of Acetyl-Coenzyme a Carboxylase in Complex with Cp-640186
Structure, 12, 2004
4WYO
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BU of 4wyo by Molmil
Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 1
Descriptor: 2'-tert-butyl-1-(2H-indazol-5-ylcarbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one, Acetyl-CoA carboxylase
Authors:Vajdos, F.F.
Deposit date:2014-11-17
Release date:2015-01-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes.
J.Med.Chem., 57, 2014
5TRC
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BU of 5trc by Molmil
Crystal structure of phosphorylated AC3-AC5 domains of yeast acetyl-CoA carboxylase
Descriptor: Acetyl-CoA carboxylase, CHLORIDE ION
Authors:Wei, J, Tong, L.
Deposit date:2016-10-26
Release date:2016-12-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation.
Cell Discov, 2, 2016

 

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