4WYO

Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 1

Summary for 4WYO

• Entry DOI: 10.2210/pdb4wyo/pdb
• Related: 4WZ8
• Descriptor: Acetyl-CoA carboxylase, 2'-tert-butyl-1-(2H-indazol-5-ylcarbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one (3 entities in total)
• Functional Keywords: acc, acetyl-coa, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast)
• Cellular location: Cytoplasm: Q00955
• Total number of polymer chains: 2
• Total formula weight: 175256.62

Authors

Vajdos, F.F. (deposition date: 2014-11-17, release date: 2015-01-14, Last modification date: 2024-02-28)

• Primary citation: Griffith, D.A.,Kung, D.W.,Esler, W.P.,Amor, P.A.,Bagley, S.W.,Beysen, C.,Carvajal-Gonzalez, S.,Doran, S.D.,Limberakis, C.,Mathiowetz, A.M.,McPherson, K.,Price, D.A.,Ravussin, E.,Sonnenberg, G.E.,Southers, J.A.,Sweet, L.J.,Turner, S.M.,Vajdos, F.F.; Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes.; J.Med.Chem., 57:10512-10526, 2014; PubMed: 25423286; DOI: 10.1021/jm5016022

Experimental method

X-RAY DIFFRACTION (2.89 Å)