3TVW

Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 4

Summary for 3TVW

Entry DOI	10.2210/pdb3tvw/pdb
Descriptor	Acetyl-CoA carboxylase, [4-(2H-chromen-3-ylmethyl)piperazin-1-yl]-[3-(1H-pyrazol-5-yl)phenyl]methanone (3 entities in total)
Functional Keywords	carboxyltransferase, ligase
Biological source	Saccharomyces cerevisiae S288c (Baker's yeast)
Cellular location	Cytoplasm: Q00955
Total number of polymer chains	3
Total formula weight	262863.95
Authors	Rajamohan, F.,Marr, E.,Reyes, A.,Landro, J.A.,Anderson, M.D.,Corbett, J.W.,Dirico, K.J.,Harwood, J.H.,Tu, M.,Vajdos, F.F. (deposition date: 2011-09-20, release date: 2011-10-19, Last modification date: 2023-09-13)
Primary citation	Rajamohan, F.,Marr, E.,Reyes, A.R.,Landro, J.A.,Anderson, M.D.,Corbett, J.W.,Dirico, K.J.,Harwood, J.H.,Tu, M.,Vajdos, F.F. Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion. J.Biol.Chem., 286:41510-41519, 2011 Cited by PubMed: 21953464 DOI: 10.1074/jbc.M111.275396 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation