5CTE

Humanized yeast ACC carboxyltransferase domain bound to 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate

Summary for 5CTE

• Entry DOI: 10.2210/pdb5cte/pdb
• Related: 5CTB 5CTC
• Descriptor: Acetyl-CoA carboxylase, 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate, SULFATE ION, ... (4 entities in total)
• Functional Keywords: acc, inhibitors, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast)
• Cellular location: Cytoplasm: Q00955
• Total number of polymer chains: 2
• Total formula weight: 175390.85

Authors

Vajdos, F.F. (deposition date: 2015-07-23, release date: 2015-10-14, Last modification date: 2024-03-06)

• Primary citation: Kung, D.W.,Griffith, D.A.,Esler, W.P.,Vajdos, F.F.,Mathiowetz, A.M.,Doran, S.D.,Amor, P.A.,Bagley, S.W.,Banks, T.,Cabral, S.,Ford, K.,Garcia-Irizarry, C.N.,Landis, M.S.,Loomis, K.,McPherson, K.,Niosi, M.,Rockwell, K.L.,Rose, C.,Smith, A.C.,Southers, J.A.,Tapley, S.,Tu, M.,Valentine, J.J.; Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.; Bioorg.Med.Chem.Lett., 25:5352-5356, 2015; PubMed: 26411795; DOI: 10.1016/j.bmcl.2015.09.035

Experimental method

X-RAY DIFFRACTION (2.34 Å)